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Influenza A(H5N1) viruses with A(H9N2) single gene (matrix or PB1) reassortment isolated from Cambodian live bird markets

tetano

Editor, Senior Moderator
Virology. 2018 Jul 31;523:22-26. doi: 10.1016/j.virol.2018.07.028. [Epub ahead of print]
[h=1]Influenza A(H5N1) viruses with A(H9N2) single gene (matrix or PB1) reassortment isolated from Cambodian live bird markets.[/h] Suttie A[SUP]1[/SUP], Karlsson EA[SUP]2[/SUP], Deng YM[SUP]3[/SUP], Horm SV[SUP]2[/SUP], Yann S[SUP]2[/SUP], Tok S[SUP]2[/SUP], Sorn S[SUP]4[/SUP], Holl D[SUP]4[/SUP], Tum S[SUP]5[/SUP], Hurt AC[SUP]3[/SUP], Greenhill AR[SUP]6[/SUP], Barr IG[SUP]3[/SUP], Horwood PF[SUP]7[/SUP], Dussart P[SUP]8[/SUP].
[h=3]Author information[/h]

[h=3]Abstract[/h] Live bird market surveillance for avian influenza viruses in Cambodia in 2015 has led to the detection of two 7:1 reassortant influenza A(H5N1) clade 2.3.2.1c viruses. These reassortant strains, designated A/duck/Cambodia/Z564W35M1/2015 and A/chicken/Cambodia/Z850W49M1/2015, both contained a single gene (PB1 and matrix gene, respectively) from concurrently circulating A(H9N2) influenza viruses. All other viral genes from both isolates clustered with A(H5N1) clade 2.3.2.1 viruses. Continued and prolonged co-circulation of influenza A(H5N1) and A(H9N2) viruses in Cambodian live bird markets may present a risk for the emergence of novel influenza reassortant viruses with negative agricultural and/or public health implications.


[h=4]KEYWORDS:[/h] A(H5N1); A(H9N2); Cambodia; Influenza; Live bird markets; Reassortment

PMID: 30075357 DOI: 10.1016/j.virol.2018.07.028
 
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