tetano
Editor, Senior Moderator
Pediatr Infect Dis J. 2012 Sep 14. [Epub ahead of print]
Influenza A/H1N1 Vaccination Response is Inadequate in Down Syndrome Children When the Latest Cut-Off Values Are Used.
Kusters MA, Bok VL, Bolz W, Huijskens E, Peeters M, de Vries E.
Source
1Dept Pediatrics, Jeroen Bosch Hospital, [Combining Grave Accent]s-Hertogenbosch 2Dept Pediatrics, M?xima Medical Centre, Veldhoven 3Dept Pediatrics, Elkerliek Hospital, Helmond 4Medical Microbiology and Immunology Laboratory, St. Elisabeth Hospital, Tilburg, The Netherlands.
Abstract
We determined the response of 48 Down syndrome (DS) children to 2 doses of influenza A/H1N1 vaccination. 92% reached the previously defined protective level (HI titer ≥1:40), but only 27% reached the level of ≥1:110 which was recently described to predict the conventional 50% clinical protection rate in children. Further studies, and potentially adaptations of the schedule, are needed.
PMID:
22986705
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22986705
Influenza A/H1N1 Vaccination Response is Inadequate in Down Syndrome Children When the Latest Cut-Off Values Are Used.
Kusters MA, Bok VL, Bolz W, Huijskens E, Peeters M, de Vries E.
Source
1Dept Pediatrics, Jeroen Bosch Hospital, [Combining Grave Accent]s-Hertogenbosch 2Dept Pediatrics, M?xima Medical Centre, Veldhoven 3Dept Pediatrics, Elkerliek Hospital, Helmond 4Medical Microbiology and Immunology Laboratory, St. Elisabeth Hospital, Tilburg, The Netherlands.
Abstract
We determined the response of 48 Down syndrome (DS) children to 2 doses of influenza A/H1N1 vaccination. 92% reached the previously defined protective level (HI titer ≥1:40), but only 27% reached the level of ≥1:110 which was recently described to predict the conventional 50% clinical protection rate in children. Further studies, and potentially adaptations of the schedule, are needed.
PMID:
22986705
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22986705