tetano
Editor, Senior Moderator
Immunology. 2017 Apr 4. doi: 10.1111/imm.12742. [Epub ahead of print]
[h=1]Inflammatory Responses to Influenza Vaccination at the Extremes of Age.[/h] McDonald JU[SUP]1[/SUP], Zhong Z[SUP]1[/SUP], Groves HT[SUP]1[/SUP], Tregoning JS[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Age affects the immune response to vaccination, with individuals at the extremes of age responding poorly. The initial inflammatory response to antigenic materials shapes the subsequent adaptive response and so understanding is required about the effect of age on the profile of acute inflammatory mediators. In this study we measured the local and systemic inflammatory response after influenza vaccination or infection in neonatal, young adult and aged mice. Mice were immunised intramuscularly with inactivated influenza vaccine with and without the adjuvant MF59 and then challenged with H1N1 influenza. Age was the major factor affecting the inflammatory profile after vaccination: neonatal mice had more IL-1a, CRP and GM-CSF, young adults more TNF, and elderly mice IL-1Ra, IL-2Ra and IP10. Notably the addition of MF59 induced IL-5, G-CSF, KC, and MCP-1 in all ages of animals and levels of these cytokines correlated with antibody responses. Age also had an impact on the efficacy of vaccination, neonatal and young adult mice were protected against challenge, but aged mice were not. There were striking differences in the localisation of the cytokine response depending on the route of exposure: vaccination led to a high serum response whilst intranasal infection led to a low serum response but a high lung response. In conclusion we demonstrate that age affects the inflammatory response to both influenza vaccination and infection. These age induced differences need to be considered when developing vaccination strategies for different age groups. This article is protected by copyright. All rights reserved.
This article is protected by copyright. All rights reserved.
[h=4]KEYWORDS:[/h] Cytokine; Lung; mucosa; vaccination; viral
PMID: 28375554 DOI: 10.1111/imm.12742
[h=1]Inflammatory Responses to Influenza Vaccination at the Extremes of Age.[/h] McDonald JU[SUP]1[/SUP], Zhong Z[SUP]1[/SUP], Groves HT[SUP]1[/SUP], Tregoning JS[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Age affects the immune response to vaccination, with individuals at the extremes of age responding poorly. The initial inflammatory response to antigenic materials shapes the subsequent adaptive response and so understanding is required about the effect of age on the profile of acute inflammatory mediators. In this study we measured the local and systemic inflammatory response after influenza vaccination or infection in neonatal, young adult and aged mice. Mice were immunised intramuscularly with inactivated influenza vaccine with and without the adjuvant MF59 and then challenged with H1N1 influenza. Age was the major factor affecting the inflammatory profile after vaccination: neonatal mice had more IL-1a, CRP and GM-CSF, young adults more TNF, and elderly mice IL-1Ra, IL-2Ra and IP10. Notably the addition of MF59 induced IL-5, G-CSF, KC, and MCP-1 in all ages of animals and levels of these cytokines correlated with antibody responses. Age also had an impact on the efficacy of vaccination, neonatal and young adult mice were protected against challenge, but aged mice were not. There were striking differences in the localisation of the cytokine response depending on the route of exposure: vaccination led to a high serum response whilst intranasal infection led to a low serum response but a high lung response. In conclusion we demonstrate that age affects the inflammatory response to both influenza vaccination and infection. These age induced differences need to be considered when developing vaccination strategies for different age groups. This article is protected by copyright. All rights reserved.
This article is protected by copyright. All rights reserved.
[h=4]KEYWORDS:[/h] Cytokine; Lung; mucosa; vaccination; viral
PMID: 28375554 DOI: 10.1111/imm.12742