tetano
Editor, Senior Moderator
Infect Drug Resist
. 2021 Apr 13;14:1389-1392.
doi: 10.2147/IDR.S304414. eCollection 2021.
The Role for Tocilizumab in COVID-19 Patients: Reflections on Monza Cohort Data
Serena Capici[SUP] #[/SUP][SUP] 1 [/SUP], Luca Sala[SUP] #[/SUP][SUP] 1 [/SUP], Stefania Galimberti[SUP] 2 [/SUP], Maria Grazia Valsecchi[SUP] 2 [/SUP], Nicola Squillace[SUP] 3 [/SUP], Giulia Gustinetti[SUP] 3 [/SUP], Marina Elena Cazzaniga[SUP] 1 4 [/SUP], Paolo Bonfanti[SUP] 3 4 [/SUP]
Affiliations
Abstract
The severe acute respiratory syndrome coronavirus 2 pandemic has dominated the global health scenario from the beginning of 2020 and still represents a major health emergency. Cytokine inhibitors as tocilizumab have been used to treat COVID-19 severe pneumonia with conflicting results. We performed a retrospective study whose results can contribute to the general overview regarding the role of these agents in severe COVID-19 pneumonia, suggesting an interesting, even not statistically significant evidence of the effectiveness of tocilizumab treatment in this disease and sow a seed of reflection about their use in future waves of pandemic. We compared two cohorts of patients treated with local standard of care and with tocilizumab in the experimental one. With a median follow-up of 92 days, deaths were 6 and 16 in the tocilizumab and the standard of care group, respectively. With a longer follow-up than previous studies, a trend in difference with regards to mortality of the groups was observed.
Keywords: COVID-19; Sars-Cov-2; pneumonia; tocilizumab.
. 2021 Apr 13;14:1389-1392.
doi: 10.2147/IDR.S304414. eCollection 2021.
The Role for Tocilizumab in COVID-19 Patients: Reflections on Monza Cohort Data
Serena Capici[SUP] #[/SUP][SUP] 1 [/SUP], Luca Sala[SUP] #[/SUP][SUP] 1 [/SUP], Stefania Galimberti[SUP] 2 [/SUP], Maria Grazia Valsecchi[SUP] 2 [/SUP], Nicola Squillace[SUP] 3 [/SUP], Giulia Gustinetti[SUP] 3 [/SUP], Marina Elena Cazzaniga[SUP] 1 4 [/SUP], Paolo Bonfanti[SUP] 3 4 [/SUP]
Affiliations
- PMID: 33880043
- PMCID: PMC8053531
- DOI: 10.2147/IDR.S304414
Abstract
The severe acute respiratory syndrome coronavirus 2 pandemic has dominated the global health scenario from the beginning of 2020 and still represents a major health emergency. Cytokine inhibitors as tocilizumab have been used to treat COVID-19 severe pneumonia with conflicting results. We performed a retrospective study whose results can contribute to the general overview regarding the role of these agents in severe COVID-19 pneumonia, suggesting an interesting, even not statistically significant evidence of the effectiveness of tocilizumab treatment in this disease and sow a seed of reflection about their use in future waves of pandemic. We compared two cohorts of patients treated with local standard of care and with tocilizumab in the experimental one. With a median follow-up of 92 days, deaths were 6 and 16 in the tocilizumab and the standard of care group, respectively. With a longer follow-up than previous studies, a trend in difference with regards to mortality of the groups was observed.
Keywords: COVID-19; Sars-Cov-2; pneumonia; tocilizumab.