tetano
Editor, Senior Moderator
Infect Drug Resist
. 2022 May 12;15:2469-2474.
doi: 10.2147/IDR.S359919. eCollection 2022.
Evaluating the Response and Safety of Inactivated COVID-19 Vaccines in Liver Transplant Recipients
Zhen-Hua Tu[SUP] #[/SUP][SUP] 1 [/SUP], Ping-Bo Jin[SUP] #[/SUP][SUP] 1 [/SUP], Di-Yu Chen[SUP] 1 [/SUP], Zhi-Yun Chen[SUP] 1 [/SUP], Zhi-Wei Li[SUP] 1 [/SUP], Jie Wu[SUP] 2 [/SUP], Bin Lou[SUP] 3 [/SUP], Bao-Shan Zhang[SUP] 4 [/SUP], Lin Zhang[SUP] 1 [/SUP], Wei Zhang[SUP] 1 [/SUP], Ting-Bo Liang[SUP] 1 5 6 7 [/SUP]
Affiliations
Abstract
Purpose: To evaluate the response and safety of an inactivated vaccine (Sinovac Life Sciences Co., Ltd., Beijing, China) for coronavirus disease 2019 (COVID-19) in liver transplant (LTx) recipients from China.
Patients and methods: Thirty-five recipients post LTx from the First Affiliated Hospital of Zhejiang University School of Medicine who received inactivated vaccine from June to October 2021 were screened. Information regarding vaccine side effects and clinical data were collected.
Results: Thirty-five LTx recipients were enrolled, with a mean age of 46 years, and most patients were male (30, 85.71%). All the participants had a negative history of COVID-19 infection. Predictors for negative response in the recipients were interleukin-2 receptor (IL-2R) induction during LTx, shorter time post LTx and application of a derivative from mycophenolate acid (MPA). No serious adverse events were observed during the progress of vaccination or after the vaccination.
Conclusion: LTx recipients have a substantially partial immunological response to the inactivated vaccine for COVID-19. IL-2R induction during LTx, a shorter time post LTx and the application of a derivative from MPA seem to be predictors for a negative serological immunoglobulin G (IgG) antibody response in recipients. The findings require booster vaccination in these LTx recipients.
Keywords: 2019-nCoV vaccination; SARS-CoV-2 infection; disease control; epidemiology; immune responses; liver transplantation.
. 2022 May 12;15:2469-2474.
doi: 10.2147/IDR.S359919. eCollection 2022.
Evaluating the Response and Safety of Inactivated COVID-19 Vaccines in Liver Transplant Recipients
Zhen-Hua Tu[SUP] #[/SUP][SUP] 1 [/SUP], Ping-Bo Jin[SUP] #[/SUP][SUP] 1 [/SUP], Di-Yu Chen[SUP] 1 [/SUP], Zhi-Yun Chen[SUP] 1 [/SUP], Zhi-Wei Li[SUP] 1 [/SUP], Jie Wu[SUP] 2 [/SUP], Bin Lou[SUP] 3 [/SUP], Bao-Shan Zhang[SUP] 4 [/SUP], Lin Zhang[SUP] 1 [/SUP], Wei Zhang[SUP] 1 [/SUP], Ting-Bo Liang[SUP] 1 5 6 7 [/SUP]
Affiliations
- PMID: 35592105
- PMCID: PMC9112169
- DOI: 10.2147/IDR.S359919
Abstract
Purpose: To evaluate the response and safety of an inactivated vaccine (Sinovac Life Sciences Co., Ltd., Beijing, China) for coronavirus disease 2019 (COVID-19) in liver transplant (LTx) recipients from China.
Patients and methods: Thirty-five recipients post LTx from the First Affiliated Hospital of Zhejiang University School of Medicine who received inactivated vaccine from June to October 2021 were screened. Information regarding vaccine side effects and clinical data were collected.
Results: Thirty-five LTx recipients were enrolled, with a mean age of 46 years, and most patients were male (30, 85.71%). All the participants had a negative history of COVID-19 infection. Predictors for negative response in the recipients were interleukin-2 receptor (IL-2R) induction during LTx, shorter time post LTx and application of a derivative from mycophenolate acid (MPA). No serious adverse events were observed during the progress of vaccination or after the vaccination.
Conclusion: LTx recipients have a substantially partial immunological response to the inactivated vaccine for COVID-19. IL-2R induction during LTx, a shorter time post LTx and the application of a derivative from MPA seem to be predictors for a negative serological immunoglobulin G (IgG) antibody response in recipients. The findings require booster vaccination in these LTx recipients.
Keywords: 2019-nCoV vaccination; SARS-CoV-2 infection; disease control; epidemiology; immune responses; liver transplantation.