tetano
Editor, Senior Moderator
Infect Drug Resist
. 2023 Mar 4;16:1263-1278.
doi: 10.2147/IDR.S394602. eCollection 2023.
Emergence of Post COVID-19 Vaccine Autoimmune Diseases: A Single Center Study
Safi Alqatari[SUP] 1 [/SUP], Mona Ismail[SUP] 1 [/SUP], Manal Hasan[SUP] 1 [/SUP], Raed Bukhari[SUP] 1 [/SUP], Reem Al Argan[SUP] 1 [/SUP], Abrar Alwaheed[SUP] 1 [/SUP], Dania Alkhafaji[SUP] 1 [/SUP], Syed Essam Ahmed[SUP] 1 [/SUP], Kawther Hadhiah[SUP] 1 [/SUP], Turki Alamri[SUP] 1 [/SUP], Ameera Nemer[SUP] 1 [/SUP], Fedaa Albeladi[SUP] 1 [/SUP], Noor N Bumurah[SUP] 1 [/SUP], Khalid Sharofna[SUP] 1 [/SUP], Zainab Albaggal[SUP] 1 [/SUP], Raghad Alghamdi[SUP] 1 [/SUP], Reem S AlSulaiman[SUP] 1 [/SUP]
Affiliations
Abstract
Introduction: Severe acute respiratory syndrome coronavirus 2 (SARS CoV-2) became a major concern since the announcement that it is a pandemic in early 2020. Vaccine trials were started in November 2020, and completed rapidly due to the urgency to get over the infection. Side effects to vaccines started to be reported. There were minor side effects including site of injection pain and heaviness and constitutional symptoms like fever which are considered minor. One of the rare adverse events is post vaccine new onset autoimmune diseases.
Methods: Data were obtained from one center in the eastern province of Saudi Arabia (King Fahd Hospital of University). All patient events reported occurred in the study period March 2021 to February 2022. We identified patients presenting with autoimmune diseases with exclusively new onset presentations.
Results: We identified 31 cases of immune-mediated disease: 18 females (58%); 13 males (42%). Only 4 of them (13%) had an autoimmune background before COVID-19 vaccination. The average time between vaccination and new-onset disease symptoms was 7 days. Among all the cases in our study, 7 patients (22.5%) had new-onset vasculitis, 2 cases had IgA vasculitis and 5 cases had ANCA vasculitis, 6 cases had neurological diseases (19.3%), 4 cases (12.9%) had new-onset systemic lupus erythematosus (SLE), 3 cases (9.6%) presented with new-onset inflammatory arthritis, and one had Sjogren's syndrome (3.2%).
Conclusion: Our study is unique as it is the first study to include the largest number (31 patients) of new onsets of confirmed autoimmune diseases related to Covid-19 vaccines.
Keywords: SARS CoV-2; autoimmune disease; immune-mediated disease; vaccine.
. 2023 Mar 4;16:1263-1278.
doi: 10.2147/IDR.S394602. eCollection 2023.
Emergence of Post COVID-19 Vaccine Autoimmune Diseases: A Single Center Study
Safi Alqatari[SUP] 1 [/SUP], Mona Ismail[SUP] 1 [/SUP], Manal Hasan[SUP] 1 [/SUP], Raed Bukhari[SUP] 1 [/SUP], Reem Al Argan[SUP] 1 [/SUP], Abrar Alwaheed[SUP] 1 [/SUP], Dania Alkhafaji[SUP] 1 [/SUP], Syed Essam Ahmed[SUP] 1 [/SUP], Kawther Hadhiah[SUP] 1 [/SUP], Turki Alamri[SUP] 1 [/SUP], Ameera Nemer[SUP] 1 [/SUP], Fedaa Albeladi[SUP] 1 [/SUP], Noor N Bumurah[SUP] 1 [/SUP], Khalid Sharofna[SUP] 1 [/SUP], Zainab Albaggal[SUP] 1 [/SUP], Raghad Alghamdi[SUP] 1 [/SUP], Reem S AlSulaiman[SUP] 1 [/SUP]
Affiliations
- PMID: 36910517
- PMCID: PMC9994665
- DOI: 10.2147/IDR.S394602
Abstract
Introduction: Severe acute respiratory syndrome coronavirus 2 (SARS CoV-2) became a major concern since the announcement that it is a pandemic in early 2020. Vaccine trials were started in November 2020, and completed rapidly due to the urgency to get over the infection. Side effects to vaccines started to be reported. There were minor side effects including site of injection pain and heaviness and constitutional symptoms like fever which are considered minor. One of the rare adverse events is post vaccine new onset autoimmune diseases.
Methods: Data were obtained from one center in the eastern province of Saudi Arabia (King Fahd Hospital of University). All patient events reported occurred in the study period March 2021 to February 2022. We identified patients presenting with autoimmune diseases with exclusively new onset presentations.
Results: We identified 31 cases of immune-mediated disease: 18 females (58%); 13 males (42%). Only 4 of them (13%) had an autoimmune background before COVID-19 vaccination. The average time between vaccination and new-onset disease symptoms was 7 days. Among all the cases in our study, 7 patients (22.5%) had new-onset vasculitis, 2 cases had IgA vasculitis and 5 cases had ANCA vasculitis, 6 cases had neurological diseases (19.3%), 4 cases (12.9%) had new-onset systemic lupus erythematosus (SLE), 3 cases (9.6%) presented with new-onset inflammatory arthritis, and one had Sjogren's syndrome (3.2%).
Conclusion: Our study is unique as it is the first study to include the largest number (31 patients) of new onsets of confirmed autoimmune diseases related to Covid-19 vaccines.
Keywords: SARS CoV-2; autoimmune disease; immune-mediated disease; vaccine.