tetano
Editor, Senior Moderator
Infect Drug Resist
. 2024 Oct 7:17:4317-4325.
doi: 10.2147/IDR.S481591. eCollection 2024. Efficacy of Azvudine Therapy in Patients with Severe and Non-Severe COVID-19: A Propensity Score-Matched Analysis
Siqin Zhang[SUP] #[/SUP][SUP] 1 [/SUP], Songsong Tan[SUP] #[/SUP][SUP] 1 [/SUP], Bin Yang[SUP] 2 [/SUP], Yaoyao Wu[SUP] 3 [/SUP], Guohang Yuan[SUP] 3 [/SUP], Fengjiao Chen[SUP] 4 [/SUP], Lin Liu[SUP] 3 5 [/SUP]
Affiliations
Objective: Azvudine is used to treat patients with the coronavirus disease 2019 (COVID-19). This study evaluated the clinical efficacy of azvudine in hospitalized patients with different severities of COVID-19 because few studies have described this in patients with severe and non-severe COVID-19.
Methods: This retrospective study included hospitalized patients with COVID-19 in Guizhou Provincial People's Hospital between December 2022 and January 2023. Azvudine-treated patients and controls were matched for sex, age, and disease severity at admission. Laboratory results and outcomes, including all-cause mortality, invasive mechanical ventilation, intensive care unit admission, and hospital stay length, were evaluated. Stratified analysis was used to explore the difference in the efficacy of azvudine in severe and non-severe COVID-19 patients.
Results: No significant differences in all-cause mortality were observed between the 303 azvudine recipients and 303 matched controls. However, azvudine-treated patients had shorter hospital stays (8.34±4.79 vs 9.17±6.25 days, P=0.046) and higher lymphocyte improvement rates (21.5% vs 13.9%, P=0.019), with a more pronounced effect in patients with non-severe COVID-19 (length of hospital stay, 8.07±4.35 vs 10.00±6.29 days, P=0.001; lymphocyte improvement rate, 23.8% vs 12.8%, P=0.015).
Conclusion: Azvudine treatment shortens hospital stay length and increases the rate of lymphocyte count improvement in patients with non-severe COVID-19, suggesting that azvudine may be a treatment option for these patients.
Keywords: COVID-19; azvudine; clinical outcome; effectiveness; hospital stay length; severity.
. 2024 Oct 7:17:4317-4325.
doi: 10.2147/IDR.S481591. eCollection 2024. Efficacy of Azvudine Therapy in Patients with Severe and Non-Severe COVID-19: A Propensity Score-Matched Analysis
Siqin Zhang[SUP] #[/SUP][SUP] 1 [/SUP], Songsong Tan[SUP] #[/SUP][SUP] 1 [/SUP], Bin Yang[SUP] 2 [/SUP], Yaoyao Wu[SUP] 3 [/SUP], Guohang Yuan[SUP] 3 [/SUP], Fengjiao Chen[SUP] 4 [/SUP], Lin Liu[SUP] 3 5 [/SUP]
Affiliations
- PMID: 39399885
- PMCID: PMC11469939
- DOI: 10.2147/IDR.S481591
Objective: Azvudine is used to treat patients with the coronavirus disease 2019 (COVID-19). This study evaluated the clinical efficacy of azvudine in hospitalized patients with different severities of COVID-19 because few studies have described this in patients with severe and non-severe COVID-19.
Methods: This retrospective study included hospitalized patients with COVID-19 in Guizhou Provincial People's Hospital between December 2022 and January 2023. Azvudine-treated patients and controls were matched for sex, age, and disease severity at admission. Laboratory results and outcomes, including all-cause mortality, invasive mechanical ventilation, intensive care unit admission, and hospital stay length, were evaluated. Stratified analysis was used to explore the difference in the efficacy of azvudine in severe and non-severe COVID-19 patients.
Results: No significant differences in all-cause mortality were observed between the 303 azvudine recipients and 303 matched controls. However, azvudine-treated patients had shorter hospital stays (8.34±4.79 vs 9.17±6.25 days, P=0.046) and higher lymphocyte improvement rates (21.5% vs 13.9%, P=0.019), with a more pronounced effect in patients with non-severe COVID-19 (length of hospital stay, 8.07±4.35 vs 10.00±6.29 days, P=0.001; lymphocyte improvement rate, 23.8% vs 12.8%, P=0.015).
Conclusion: Azvudine treatment shortens hospital stay length and increases the rate of lymphocyte count improvement in patients with non-severe COVID-19, suggesting that azvudine may be a treatment option for these patients.
Keywords: COVID-19; azvudine; clinical outcome; effectiveness; hospital stay length; severity.