tetano
Editor, Senior Moderator
Infect Disord Drug Targets
. 2022 Jan 5.
doi: 10.2174/1871526522666220105111358. Online ahead of print.
COVID-19 Infection in Pregnancy: A Review
Sabrina Jahan Mily[SUP] 1 [/SUP], Kazi Mahmuda Akter[SUP] 2 [/SUP], Nowshin Jabin[SUP] 3 [/SUP], Saikat Mitra[SUP] 4 [/SUP], Talha Bin Emran[SUP] 5 [/SUP], Monisha Nandi[SUP] 5 [/SUP], Sumit Kumar Baral[SUP] 6 [/SUP], Md Zia Uddin[SUP] 5 [/SUP], Jewel Mallick[SUP] 5 [/SUP], Arkajyoti Paul[SUP] 5 [/SUP], Syed Uzair Ali Shah[SUP] 7 [/SUP], Abdur Rauf[SUP] 8 [/SUP], Ishaq N Khan[SUP] 9 [/SUP], Mohammad S Mubarak[SUP] 10 [/SUP]
Affiliations
Abstract
Coronavirus disease 2019 (COVID-19), which is a highly contagious viral illness caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has had a catastrophic effect on the world's demographics, resulting in more than 3.8 million deaths worldwide, and establishing itself as the most serious global health crisis since the 1918 influenza pandemic. Several questions remain unanswered regarding the effects of COVID-19 disease during pregnancy. Although most infections are mild in high-risk populations, severe disease frequently leads to intubation, intensive care unit admission, and, in some cases, death. Hormonal and physiological changes in the immune and respiratory systems, cardiovascular function, and coagulation may affect the progression of COVID-19 disease in pregnancy. However, consequences of coronavirus infection on implantation, fetal growth and development, labor, and newborn health have yet to be determined, and, consequently, a coordinated global effort is needed in this respect . Principles of management concerning COVID-19 in pregnancy include early isolation, aggressive infection control procedures, oxygen therapy, avoidance of fluid overload, consideration of empiric antibiotics (secondary to bacterial infection risk), laboratory testing for the virus and co-infection, fetal and uterine contraction monitoring, prevention and / or treatment of thromboembolism early mechanical ventilation for progressive respiratory failure, individualized delivery planning, and a team-based approach with multispecialty consultations. This review focuses on COVID-19 during pregnancy, its management, and the area where further investigations are needed to reduce the risk to mothers and their newborns.
Keywords: COVID-19; coronavirus; infection; management; pandemic; pregnancy.
. 2022 Jan 5.
doi: 10.2174/1871526522666220105111358. Online ahead of print.
COVID-19 Infection in Pregnancy: A Review
Sabrina Jahan Mily[SUP] 1 [/SUP], Kazi Mahmuda Akter[SUP] 2 [/SUP], Nowshin Jabin[SUP] 3 [/SUP], Saikat Mitra[SUP] 4 [/SUP], Talha Bin Emran[SUP] 5 [/SUP], Monisha Nandi[SUP] 5 [/SUP], Sumit Kumar Baral[SUP] 6 [/SUP], Md Zia Uddin[SUP] 5 [/SUP], Jewel Mallick[SUP] 5 [/SUP], Arkajyoti Paul[SUP] 5 [/SUP], Syed Uzair Ali Shah[SUP] 7 [/SUP], Abdur Rauf[SUP] 8 [/SUP], Ishaq N Khan[SUP] 9 [/SUP], Mohammad S Mubarak[SUP] 10 [/SUP]
Affiliations
- PMID: 34986776
- DOI: 10.2174/1871526522666220105111358
Abstract
Coronavirus disease 2019 (COVID-19), which is a highly contagious viral illness caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has had a catastrophic effect on the world's demographics, resulting in more than 3.8 million deaths worldwide, and establishing itself as the most serious global health crisis since the 1918 influenza pandemic. Several questions remain unanswered regarding the effects of COVID-19 disease during pregnancy. Although most infections are mild in high-risk populations, severe disease frequently leads to intubation, intensive care unit admission, and, in some cases, death. Hormonal and physiological changes in the immune and respiratory systems, cardiovascular function, and coagulation may affect the progression of COVID-19 disease in pregnancy. However, consequences of coronavirus infection on implantation, fetal growth and development, labor, and newborn health have yet to be determined, and, consequently, a coordinated global effort is needed in this respect . Principles of management concerning COVID-19 in pregnancy include early isolation, aggressive infection control procedures, oxygen therapy, avoidance of fluid overload, consideration of empiric antibiotics (secondary to bacterial infection risk), laboratory testing for the virus and co-infection, fetal and uterine contraction monitoring, prevention and / or treatment of thromboembolism early mechanical ventilation for progressive respiratory failure, individualized delivery planning, and a team-based approach with multispecialty consultations. This review focuses on COVID-19 during pregnancy, its management, and the area where further investigations are needed to reduce the risk to mothers and their newborns.
Keywords: COVID-19; coronavirus; infection; management; pandemic; pregnancy.