tetano
Editor, Senior Moderator
Infect Dis Ther
. 2021 Jun 11.
doi: 10.1007/s40121-021-00477-9. Online ahead of print.
Impact of Inflammatory Response Modifiers on the Incidence of Hospital-Acquired Infections in Patients with COVID-19
Fernanda Meira[SUP] 1 [/SUP], Estela Moreno-García[SUP] 1 [/SUP], Laura Linares[SUP] 1 [/SUP], Irene Macaya[SUP] 1 [/SUP], Adria Tomé[SUP] 1 [/SUP], Marta Hernández-Meneses[SUP] 1 [/SUP], Laia Albiach[SUP] 1 [/SUP], Laura Morata[SUP] 1 [/SUP], Laura Letona[SUP] 1 [/SUP], Marta Bodro[SUP] 1 [/SUP], Alberto Cózar-Llistó[SUP] 1 [/SUP], Celia Cardozo[SUP] 1 [/SUP], Mariana Chumbita[SUP] 1 [/SUP], Cristina Pitart[SUP] 2 [/SUP], Juan Ambrosioni[SUP] 1 [/SUP], Verónica Rico[SUP] 1 [/SUP], Daiana Agüero[SUP] 1 [/SUP], Pedro Puerta-Alcalde[SUP] 1 [/SUP], Nicole Garcia-Pouton[SUP] 1 [/SUP], Francesc Marco[SUP] 2 [/SUP], Carolina Garcia-Vidal[SUP] 1 [/SUP], Alex Soriano[SUP] 3 [/SUP], José Antonio Martínez[SUP] 1 [/SUP]
Affiliations
Abstract
Introduction: The study aim was to assess the influence of inflammatory response modifiers, including anti-interleukin-6 (IL-6) biologics and corticosteroids, on the incidence of hospital-acquired infections in patients with coronavirus disease 2019 (COVID-19).
Methods: Case-control study performed at a university hospital from February 26 to May 26, 2020. Cases were defined as patients with COVID-19 who developed hospital-acquired infections. For each case, two controls were selected among patients without infections. Cases and controls were matched obeying three criteria in a hierarchical sequence: length of hospital stay up until the first infection; comorbidity; and need for Intensive care unit (ICU) admission. Conditional logistic regression analysis was used to estimate the association of exposures with being a case.
Results: A total of 71 cases and 142 controls were included. Independent predictors for acquiring a hospital infection were chronic liver disease [odds ratio (OR) 16.56, 95% CI 1.87-146.5, p = 0.012], morbid obesity (OR 6.11, 95% CI 1.06-35.4, p = 0.043), current or past smoking (OR 4.15, 95% CI 1.45-11.88, p = 0.008), exposure to hydroxychloroquine (OR 0.2, 95% CI 0.041-1, p = 0.053), and invasive mechanical ventilation (OR 61.5, 95% CI 11.08-341, p ≤ 0.0001).
Conclusions: Inflammatory response modifiers had no influence on acquisition of nosocomial infections in admitted patients with COVID-19. Hospital-acquired infections primarily occurred in the critically ill and invasive mechanical ventilation was the main exposure conferring risk.
Keywords: COVID-19; Inflammatory response modifiers; Nosocomial infections; SARS-CoV-2.
. 2021 Jun 11.
doi: 10.1007/s40121-021-00477-9. Online ahead of print.
Impact of Inflammatory Response Modifiers on the Incidence of Hospital-Acquired Infections in Patients with COVID-19
Fernanda Meira[SUP] 1 [/SUP], Estela Moreno-García[SUP] 1 [/SUP], Laura Linares[SUP] 1 [/SUP], Irene Macaya[SUP] 1 [/SUP], Adria Tomé[SUP] 1 [/SUP], Marta Hernández-Meneses[SUP] 1 [/SUP], Laia Albiach[SUP] 1 [/SUP], Laura Morata[SUP] 1 [/SUP], Laura Letona[SUP] 1 [/SUP], Marta Bodro[SUP] 1 [/SUP], Alberto Cózar-Llistó[SUP] 1 [/SUP], Celia Cardozo[SUP] 1 [/SUP], Mariana Chumbita[SUP] 1 [/SUP], Cristina Pitart[SUP] 2 [/SUP], Juan Ambrosioni[SUP] 1 [/SUP], Verónica Rico[SUP] 1 [/SUP], Daiana Agüero[SUP] 1 [/SUP], Pedro Puerta-Alcalde[SUP] 1 [/SUP], Nicole Garcia-Pouton[SUP] 1 [/SUP], Francesc Marco[SUP] 2 [/SUP], Carolina Garcia-Vidal[SUP] 1 [/SUP], Alex Soriano[SUP] 3 [/SUP], José Antonio Martínez[SUP] 1 [/SUP]
Affiliations
- PMID: 34115314
- DOI: 10.1007/s40121-021-00477-9
Abstract
Introduction: The study aim was to assess the influence of inflammatory response modifiers, including anti-interleukin-6 (IL-6) biologics and corticosteroids, on the incidence of hospital-acquired infections in patients with coronavirus disease 2019 (COVID-19).
Methods: Case-control study performed at a university hospital from February 26 to May 26, 2020. Cases were defined as patients with COVID-19 who developed hospital-acquired infections. For each case, two controls were selected among patients without infections. Cases and controls were matched obeying three criteria in a hierarchical sequence: length of hospital stay up until the first infection; comorbidity; and need for Intensive care unit (ICU) admission. Conditional logistic regression analysis was used to estimate the association of exposures with being a case.
Results: A total of 71 cases and 142 controls were included. Independent predictors for acquiring a hospital infection were chronic liver disease [odds ratio (OR) 16.56, 95% CI 1.87-146.5, p = 0.012], morbid obesity (OR 6.11, 95% CI 1.06-35.4, p = 0.043), current or past smoking (OR 4.15, 95% CI 1.45-11.88, p = 0.008), exposure to hydroxychloroquine (OR 0.2, 95% CI 0.041-1, p = 0.053), and invasive mechanical ventilation (OR 61.5, 95% CI 11.08-341, p ≤ 0.0001).
Conclusions: Inflammatory response modifiers had no influence on acquisition of nosocomial infections in admitted patients with COVID-19. Hospital-acquired infections primarily occurred in the critically ill and invasive mechanical ventilation was the main exposure conferring risk.
Keywords: COVID-19; Inflammatory response modifiers; Nosocomial infections; SARS-CoV-2.