tetano
Editor, Senior Moderator
Infect Dis Ther
. 2024 Mar 14.
doi: 10.1007/s40121-024-00937-y. Online ahead of print. Household Influenza Transmission and Healthcare Resource Utilization Among Patients Treated with Baloxavir vs Oseltamivir: A United States Outpatient Prospective Survey
Jennie H Best[SUP] 1 [/SUP], Mitra Sadeghi[SUP] 1 [/SUP], Xiaowu Sun[SUP] 2 [/SUP], Arpamas Seetasith[SUP] 1 [/SUP], Lisa Albensi[SUP] 2 [/SUP], Seema Joshi[SUP] 3 [/SUP], Marcus J Zervos[SUP] 4 5 6 [/SUP]
Affiliations
Introduction: Influenza is a common, seasonal infectious disease with broad medical, economic, and social consequences. Real-world evidence on the effect of influenza treatment on household transmission and healthcare resource utilization is limited in outpatient settings in the USA. This study examined the real-world effectiveness of baloxavir vs oseltamivir in reducing influenza household transmission and healthcare resource utilization.
Methods: This prospective electronic survey on patient-reported outcomes was conducted between October 2022 and May 2023 via CVS Pharmacy in the USA. Adult participants (≥ 18 years old) were eligible if they filled a prescription for baloxavir or oseltamivir at a CVS Pharmacy within 2 days of influenza symptom onset. Participant demographics, household transmission, and all-cause healthcare resource utilization were collected. Transmission and utilization outcomes were assessed using χ[SUP]2[/SUP] and Fisher exact tests.
Results: Of 87,871 unique patients contacted, 1346 (1.5%) consented. Of 374 eligible patients, 286 (90 baloxavir- and 196 oseltamivir-treated patients) completed the survey and were included in the analysis. Mean age of participants was 45.4 years, 65.6% were female, and 86.7% were White. Lower household transmission was observed with baloxavir compared with oseltamivir therapy (17.8% vs 26.5%; relative risk = 0.67; 95% CI 0.41-1.11). Healthcare resource utilization, particularly emergency department visits (0.0% vs 4.6%), was also numerically lower in the baloxavir-treated group; no hospitalizations were reported in either cohort.
Conclusions: The findings from this real-world study suggest that antiviral treatment of influenza with baloxavir may decrease household transmission and reduce healthcare resource utilization compared with oseltamivir.
Keywords: Baloxavir; Influenza; Oseltamivir; Real-world data; Transmission.
. 2024 Mar 14.
doi: 10.1007/s40121-024-00937-y. Online ahead of print. Household Influenza Transmission and Healthcare Resource Utilization Among Patients Treated with Baloxavir vs Oseltamivir: A United States Outpatient Prospective Survey
Jennie H Best[SUP] 1 [/SUP], Mitra Sadeghi[SUP] 1 [/SUP], Xiaowu Sun[SUP] 2 [/SUP], Arpamas Seetasith[SUP] 1 [/SUP], Lisa Albensi[SUP] 2 [/SUP], Seema Joshi[SUP] 3 [/SUP], Marcus J Zervos[SUP] 4 5 6 [/SUP]
Affiliations
- PMID: 38483775
- DOI: 10.1007/s40121-024-00937-y
Introduction: Influenza is a common, seasonal infectious disease with broad medical, economic, and social consequences. Real-world evidence on the effect of influenza treatment on household transmission and healthcare resource utilization is limited in outpatient settings in the USA. This study examined the real-world effectiveness of baloxavir vs oseltamivir in reducing influenza household transmission and healthcare resource utilization.
Methods: This prospective electronic survey on patient-reported outcomes was conducted between October 2022 and May 2023 via CVS Pharmacy in the USA. Adult participants (≥ 18 years old) were eligible if they filled a prescription for baloxavir or oseltamivir at a CVS Pharmacy within 2 days of influenza symptom onset. Participant demographics, household transmission, and all-cause healthcare resource utilization were collected. Transmission and utilization outcomes were assessed using χ[SUP]2[/SUP] and Fisher exact tests.
Results: Of 87,871 unique patients contacted, 1346 (1.5%) consented. Of 374 eligible patients, 286 (90 baloxavir- and 196 oseltamivir-treated patients) completed the survey and were included in the analysis. Mean age of participants was 45.4 years, 65.6% were female, and 86.7% were White. Lower household transmission was observed with baloxavir compared with oseltamivir therapy (17.8% vs 26.5%; relative risk = 0.67; 95% CI 0.41-1.11). Healthcare resource utilization, particularly emergency department visits (0.0% vs 4.6%), was also numerically lower in the baloxavir-treated group; no hospitalizations were reported in either cohort.
Conclusions: The findings from this real-world study suggest that antiviral treatment of influenza with baloxavir may decrease household transmission and reduce healthcare resource utilization compared with oseltamivir.
Keywords: Baloxavir; Influenza; Oseltamivir; Real-world data; Transmission.