tetano
Editor, Senior Moderator
Infect Dis Poverty
. 2020 Dec 2;9(1):163.
doi: 10.1186/s40249-020-00781-5.
Comparison of patients hospitalized with COVID-19, H7N9 and H1N1
Li-Si Deng[SUP] 1 [/SUP], Jing Yuan[SUP] 2 [/SUP], Li Ding[SUP] 1 [/SUP], Yuan-Li Chen[SUP] 3 [/SUP], Chao-Hui Zhao[SUP] 1 [/SUP], Gong-Qi Chen[SUP] 1 [/SUP], Xing-Hua Li[SUP] 1 [/SUP], Xiao-He Li[SUP] 2 [/SUP], Wen-Tao Luo[SUP] 1 [/SUP], Jian-Feng Lan[SUP] 2 [/SUP], Guo-Yu Tan[SUP] 2 [/SUP], Sheng-Hong Tang[SUP] 2 [/SUP], Jin-Yu Xia[SUP] 4 [/SUP], Xi Liu[SUP] 5 [/SUP]
Affiliations
Abstract
Background: There is an urgent need to better understand the novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), for that the coronavirus disease 2019 (COVID-19) continues to cause considerable morbidity and mortality worldwide. This paper was to differentiate COVID-19 from other respiratory infectious diseases such as avian-origin influenza A (H7N9) and influenza A (H1N1) virus infections.
Methods: We included patients who had been hospitalized with laboratory-confirmed infection by SARS-CoV-2 (n = 83), H7N9 (n = 36), H1N1 (n = 44) viruses. Clinical presentation, chest CT features, and progression of patients were compared. We used the Logistic regression model to explore the possible risk factors.
Results: Both COVID-19 and H7N9 patients had a longer duration of hospitalization than H1N1 patients (P < 0.01), a higher complication rate, and more severe cases than H1N1 patients. H7N9 patients had higher hospitalization-fatality ratio than COVID-19 patients (P = 0.01). H7N9 patients had similar patterns of lymphopenia, neutrophilia, elevated alanine aminotransferase, C-reactive protein, lactate dehydrogenase, and those seen in H1N1 patients, which were all significantly different from patients with COVID-19 (P < 0.01). Either H7N9 or H1N1 patients had more obvious symptoms, like fever, fatigue, yellow sputum, and myalgia than COVID-19 patients (P < 0.01). The mean duration of viral shedding was 9.5 days for SARS-CoV-2 vs 9.9 days for H7N9 (P = 0.78). For severe cases, the meantime from illness onset to severity was 8.0 days for COVID-19 vs 5.2 days for H7N9 (P < 0.01), the comorbidity of chronic heart disease was more common in the COVID-19 patients than H7N9 (P = 0.02). Multivariate analysis showed that chronic heart disease was a possible risk factor (OR > 1) for COVID-19, compared with H1N1 and H7N9.
Conclusions: The proportion of severe cases were higher for H7N9 and SARS-CoV-2 infections, compared with H1N1. The meantime from illness onset to severity was shorter for H7N9. Chronic heart disease was a possible risk factor for COVID-19.The comparison may provide the rationale for strategies of isolation and treatment of infected patients in the future.
Keywords: COVID-19; Comparison; H1N1; H7N9; SARS-CoV-2.
. 2020 Dec 2;9(1):163.
doi: 10.1186/s40249-020-00781-5.
Comparison of patients hospitalized with COVID-19, H7N9 and H1N1
Li-Si Deng[SUP] 1 [/SUP], Jing Yuan[SUP] 2 [/SUP], Li Ding[SUP] 1 [/SUP], Yuan-Li Chen[SUP] 3 [/SUP], Chao-Hui Zhao[SUP] 1 [/SUP], Gong-Qi Chen[SUP] 1 [/SUP], Xing-Hua Li[SUP] 1 [/SUP], Xiao-He Li[SUP] 2 [/SUP], Wen-Tao Luo[SUP] 1 [/SUP], Jian-Feng Lan[SUP] 2 [/SUP], Guo-Yu Tan[SUP] 2 [/SUP], Sheng-Hong Tang[SUP] 2 [/SUP], Jin-Yu Xia[SUP] 4 [/SUP], Xi Liu[SUP] 5 [/SUP]
Affiliations
- PMID: 33261654
- DOI: 10.1186/s40249-020-00781-5
Abstract
Background: There is an urgent need to better understand the novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), for that the coronavirus disease 2019 (COVID-19) continues to cause considerable morbidity and mortality worldwide. This paper was to differentiate COVID-19 from other respiratory infectious diseases such as avian-origin influenza A (H7N9) and influenza A (H1N1) virus infections.
Methods: We included patients who had been hospitalized with laboratory-confirmed infection by SARS-CoV-2 (n = 83), H7N9 (n = 36), H1N1 (n = 44) viruses. Clinical presentation, chest CT features, and progression of patients were compared. We used the Logistic regression model to explore the possible risk factors.
Results: Both COVID-19 and H7N9 patients had a longer duration of hospitalization than H1N1 patients (P < 0.01), a higher complication rate, and more severe cases than H1N1 patients. H7N9 patients had higher hospitalization-fatality ratio than COVID-19 patients (P = 0.01). H7N9 patients had similar patterns of lymphopenia, neutrophilia, elevated alanine aminotransferase, C-reactive protein, lactate dehydrogenase, and those seen in H1N1 patients, which were all significantly different from patients with COVID-19 (P < 0.01). Either H7N9 or H1N1 patients had more obvious symptoms, like fever, fatigue, yellow sputum, and myalgia than COVID-19 patients (P < 0.01). The mean duration of viral shedding was 9.5 days for SARS-CoV-2 vs 9.9 days for H7N9 (P = 0.78). For severe cases, the meantime from illness onset to severity was 8.0 days for COVID-19 vs 5.2 days for H7N9 (P < 0.01), the comorbidity of chronic heart disease was more common in the COVID-19 patients than H7N9 (P = 0.02). Multivariate analysis showed that chronic heart disease was a possible risk factor (OR > 1) for COVID-19, compared with H1N1 and H7N9.
Conclusions: The proportion of severe cases were higher for H7N9 and SARS-CoV-2 infections, compared with H1N1. The meantime from illness onset to severity was shorter for H7N9. Chronic heart disease was a possible risk factor for COVID-19.The comparison may provide the rationale for strategies of isolation and treatment of infected patients in the future.
Keywords: COVID-19; Comparison; H1N1; H7N9; SARS-CoV-2.