tetano
Editor, Senior Moderator
Infect Dis Model
. 2023 Jan 5.
doi: 10.1016/j.idm.2022.12.007. Online ahead of print.
Assessing the effectiveness of the intervention measures of COVID-19 in China based on dynamical method
Xiaomeng Wei[SUP] 1 2 3 [/SUP], Mingtao Li[SUP] 4 [/SUP], Xin Pei[SUP] 4 [/SUP], Zhiping Liu[SUP] 5 [/SUP], Juan Zhang[SUP] 1 2 [/SUP]
Affiliations
Abstract
Normalized interventions were implemented in different cities in China to contain the outbreak of COVID-19 before December 2022. However, the differences in the intensity and timeliness of the implementations lead to differences in final size of the infections. Taking the outbreak of COVID-19 in three representative cities Xi'an, Zhengzhou and Yuzhou in January 2022, as examples, we develop a compartmental model to describe the spread of novel coronavirus and implementation of interventions to assess concretely the effectiveness of Chinese interventions and explore their impact on epidemic patterns. After applying reported human confirmed cases to verify the rationality of the model, we apply the model to speculate transmission trend and length of concealed period at the initial spread phase of the epidemic (they are estimated as 10.5, 7.8, 8.2 days, respectively), to estimate the range of basic reproduction number (2.9, 0.7, 1.6), and to define two indexes (transmission rate v [SUB]t[/SUB] and controlled rate v [SUB]c[/SUB] ) to evaluate the overall effect of the interventions. It is shown that for Zhengzhou, v [SUB]c[/SUB] is always more than v [SUB]t[/SUB] with regular interventions, and Xi'an take 8 days to achieve v [SUB]c[/SUB] > v [SUB]t[/SUB] twice as long as Yuzhou, which can interpret the fact that the epidemic situation in Xi'an was more severe. By carrying out parameter values, it is concluded that in the early stage, strengthening the precision of close contact tracking and frequency of large-scale nucleic acid testing of non-quarantined population are the most effective on controlling the outbreaks and reducing final size. And, if the close contact tracking strategy is sufficiently implemented, at the late stage large-scale nucleic acid testing of non-quarantined population is not essential.
Keywords: COVID-19; Close contact tracking; Dynamics; Large-scale nucleic acid testing; Sensitivity analysis; The basic reproduction number.
. 2023 Jan 5.
doi: 10.1016/j.idm.2022.12.007. Online ahead of print.
Assessing the effectiveness of the intervention measures of COVID-19 in China based on dynamical method
Xiaomeng Wei[SUP] 1 2 3 [/SUP], Mingtao Li[SUP] 4 [/SUP], Xin Pei[SUP] 4 [/SUP], Zhiping Liu[SUP] 5 [/SUP], Juan Zhang[SUP] 1 2 [/SUP]
Affiliations
- PMID: 36624814
- PMCID: PMC9812467
- DOI: 10.1016/j.idm.2022.12.007
Abstract
Normalized interventions were implemented in different cities in China to contain the outbreak of COVID-19 before December 2022. However, the differences in the intensity and timeliness of the implementations lead to differences in final size of the infections. Taking the outbreak of COVID-19 in three representative cities Xi'an, Zhengzhou and Yuzhou in January 2022, as examples, we develop a compartmental model to describe the spread of novel coronavirus and implementation of interventions to assess concretely the effectiveness of Chinese interventions and explore their impact on epidemic patterns. After applying reported human confirmed cases to verify the rationality of the model, we apply the model to speculate transmission trend and length of concealed period at the initial spread phase of the epidemic (they are estimated as 10.5, 7.8, 8.2 days, respectively), to estimate the range of basic reproduction number (2.9, 0.7, 1.6), and to define two indexes (transmission rate v [SUB]t[/SUB] and controlled rate v [SUB]c[/SUB] ) to evaluate the overall effect of the interventions. It is shown that for Zhengzhou, v [SUB]c[/SUB] is always more than v [SUB]t[/SUB] with regular interventions, and Xi'an take 8 days to achieve v [SUB]c[/SUB] > v [SUB]t[/SUB] twice as long as Yuzhou, which can interpret the fact that the epidemic situation in Xi'an was more severe. By carrying out parameter values, it is concluded that in the early stage, strengthening the precision of close contact tracking and frequency of large-scale nucleic acid testing of non-quarantined population are the most effective on controlling the outbreaks and reducing final size. And, if the close contact tracking strategy is sufficiently implemented, at the late stage large-scale nucleic acid testing of non-quarantined population is not essential.
Keywords: COVID-19; Close contact tracking; Dynamics; Large-scale nucleic acid testing; Sensitivity analysis; The basic reproduction number.