tetano
Editor, Senior Moderator
Infect Dis (Lond)
. 2021 Jun 15;1-10.
doi: 10.1080/23744235.2021.1940271. Online ahead of print.
Adjunctive treatment with high-titre convalescent plasma in severely and critically ill COVID-19 patients - a safe but futile intervention. A comparative cohort study
Wolfgang Paul Hoepler[SUP] 1 [/SUP], Lisa Weidner[SUP] 2 [/SUP], Marianna Theresia Traugott[SUP] 1 [/SUP], Stephanie Neuhold[SUP] 1 [/SUP], Elias Laurin Meyer[SUP] 3 [/SUP], Alexander Zoufaly[SUP] 1 4 [/SUP], Tamara Seitz[SUP] 1 [/SUP], Reinhard Kitzberger[SUP] 1 [/SUP], Sebastian Baumgartner[SUP] 1 [/SUP], Erich Pawelka[SUP] 1 [/SUP], Mario Karolyi[SUP] 1 [/SUP], Alexander Grieb[SUP] 4 [/SUP], Julian Hind[SUP] 1 [/SUP], Hermann Laferl[SUP] 1 [/SUP], Emanuela Friese[SUP] 1 [/SUP], Christoph Wenisch[SUP] 1 [/SUP], Stephan Walter Aberle[SUP] 5 [/SUP], Judith Helene Aberle[SUP] 5 [/SUP], Lukas Weseslindtner[SUP] 5 [/SUP], Christoph Jungbauer[SUP] 2 [/SUP]
Affiliations
Abstract
Background: Convalescent plasma (CP) containing antibodies derived from coronavirus disease 2019 (COVID-19) survivors has been proposed as a promising therapeutic option for severe COVID-19.
Methods: In our intensive care unit (ICU), 55 patients (46 male, median age 61 years) with PCR-confirmed COVID-19 (35 = 63.6% on mechanical ventilation, 7 = 14.5% on high-flow nasal oxygen, 12 = 20% on non-invasive ventilation, 1 = 1.8% without respiratory support) were treated with high-titre CP (200 mL per dose, range 1-6 doses, median 3 doses per patient, minimum titre > 1:100, Wantai test). 139 COVID-19 patients treated in the same ICU who did not receive CP served as control group. In 27 patients, the effect of CP on the individual levels of SARS-CoV-2 IgG antibodies was assessed by ELISA in serum sample pairs collected before and after CP transfusion.
Results: The first CP dose was administered at a median of 8 days after symptom onset. 13 patients in the plasma cohort died (28-day mortality 24.1%), compared to 42 (30.2%) in the cohort who did not receive CP (p = 0.5, Pearson Chi-squared test). Out of the 27 individuals investigated for the presence of IgG antibodies, 8 did not have detectable IgG levels before the first CP transfusion. In this subpopulation, 3 patients (37.5%) died. Not a single confirmed adverse reaction to CP was noted.
Conclusions: While adjunctive treatment with CP for severe and life-threatening COVID-19 was a very safe intervention, we did not observe any effect on mortality.
Keywords: Convalescent plasma; SARS-CoV-2; intensive care medicine; severe COVID-19.
. 2021 Jun 15;1-10.
doi: 10.1080/23744235.2021.1940271. Online ahead of print.
Adjunctive treatment with high-titre convalescent plasma in severely and critically ill COVID-19 patients - a safe but futile intervention. A comparative cohort study
Wolfgang Paul Hoepler[SUP] 1 [/SUP], Lisa Weidner[SUP] 2 [/SUP], Marianna Theresia Traugott[SUP] 1 [/SUP], Stephanie Neuhold[SUP] 1 [/SUP], Elias Laurin Meyer[SUP] 3 [/SUP], Alexander Zoufaly[SUP] 1 4 [/SUP], Tamara Seitz[SUP] 1 [/SUP], Reinhard Kitzberger[SUP] 1 [/SUP], Sebastian Baumgartner[SUP] 1 [/SUP], Erich Pawelka[SUP] 1 [/SUP], Mario Karolyi[SUP] 1 [/SUP], Alexander Grieb[SUP] 4 [/SUP], Julian Hind[SUP] 1 [/SUP], Hermann Laferl[SUP] 1 [/SUP], Emanuela Friese[SUP] 1 [/SUP], Christoph Wenisch[SUP] 1 [/SUP], Stephan Walter Aberle[SUP] 5 [/SUP], Judith Helene Aberle[SUP] 5 [/SUP], Lukas Weseslindtner[SUP] 5 [/SUP], Christoph Jungbauer[SUP] 2 [/SUP]
Affiliations
- PMID: 34128763
- DOI: 10.1080/23744235.2021.1940271
Abstract
Background: Convalescent plasma (CP) containing antibodies derived from coronavirus disease 2019 (COVID-19) survivors has been proposed as a promising therapeutic option for severe COVID-19.
Methods: In our intensive care unit (ICU), 55 patients (46 male, median age 61 years) with PCR-confirmed COVID-19 (35 = 63.6% on mechanical ventilation, 7 = 14.5% on high-flow nasal oxygen, 12 = 20% on non-invasive ventilation, 1 = 1.8% without respiratory support) were treated with high-titre CP (200 mL per dose, range 1-6 doses, median 3 doses per patient, minimum titre > 1:100, Wantai test). 139 COVID-19 patients treated in the same ICU who did not receive CP served as control group. In 27 patients, the effect of CP on the individual levels of SARS-CoV-2 IgG antibodies was assessed by ELISA in serum sample pairs collected before and after CP transfusion.
Results: The first CP dose was administered at a median of 8 days after symptom onset. 13 patients in the plasma cohort died (28-day mortality 24.1%), compared to 42 (30.2%) in the cohort who did not receive CP (p = 0.5, Pearson Chi-squared test). Out of the 27 individuals investigated for the presence of IgG antibodies, 8 did not have detectable IgG levels before the first CP transfusion. In this subpopulation, 3 patients (37.5%) died. Not a single confirmed adverse reaction to CP was noted.
Conclusions: While adjunctive treatment with CP for severe and life-threatening COVID-19 was a very safe intervention, we did not observe any effect on mortality.
Keywords: Convalescent plasma; SARS-CoV-2; intensive care medicine; severe COVID-19.