tetano
Editor, Senior Moderator
Infect Dis Immun
. 2022 Oct;2(4):289-292.
doi: 10.1097/ID9.0000000000000041. Epub 2022 Aug 12. Prolonged Viral Shedding in Three Young Adult Cases of COVID-19
Wen-Yi Dong[SUP] 1 [/SUP], Ming-Ju Zhou[SUP] 2 3 [/SUP], Lei Huang[SUP] 3 [/SUP], Chao Zhang[SUP] 1 3 [/SUP], Fu-Sheng Wang[SUP] 1 2 3 [/SUP], Zhou-Hua Xie[SUP] 1 [/SUP]
Affiliations
Severe acute respiratory syndrome coronavirus-2 infection is usually self-limited, with a short duration for viral shedding within several weeks. However, prolonged viral shedding has been observed in severe or immune-compromised coronavirus disease 2019 (COVID-19) cases. Here, we reported that three young adult cases of COVID-19 patients, who were either immunosuppressed nor severe, showed prolonged viral RNA shedding from the upper respiratory tract for 58, 81, and 137 days since initial diagnosis. To our knowledge, this is the longest duration of viral shedding reported to date in young adult patients. Further studies on factors relevant to prolonged viral positivity, as well as the correlation between viral positivity and transmission risk are needed for the optimal management of COVID-19 patients with prolonged nucleic acid positive.
Keywords: COVID-19; Immune-competent; Prolonged viral shedding; SAR-CoV-2.
. 2022 Oct;2(4):289-292.
doi: 10.1097/ID9.0000000000000041. Epub 2022 Aug 12. Prolonged Viral Shedding in Three Young Adult Cases of COVID-19
Wen-Yi Dong[SUP] 1 [/SUP], Ming-Ju Zhou[SUP] 2 3 [/SUP], Lei Huang[SUP] 3 [/SUP], Chao Zhang[SUP] 1 3 [/SUP], Fu-Sheng Wang[SUP] 1 2 3 [/SUP], Zhou-Hua Xie[SUP] 1 [/SUP]
Affiliations
- PMID: 37520896
- PMCID: PMC9612418
- DOI: 10.1097/ID9.0000000000000041
Severe acute respiratory syndrome coronavirus-2 infection is usually self-limited, with a short duration for viral shedding within several weeks. However, prolonged viral shedding has been observed in severe or immune-compromised coronavirus disease 2019 (COVID-19) cases. Here, we reported that three young adult cases of COVID-19 patients, who were either immunosuppressed nor severe, showed prolonged viral RNA shedding from the upper respiratory tract for 58, 81, and 137 days since initial diagnosis. To our knowledge, this is the longest duration of viral shedding reported to date in young adult patients. Further studies on factors relevant to prolonged viral positivity, as well as the correlation between viral positivity and transmission risk are needed for the optimal management of COVID-19 patients with prolonged nucleic acid positive.
Keywords: COVID-19; Immune-competent; Prolonged viral shedding; SAR-CoV-2.