tetano
Editor, Senior Moderator
Infect Dis Health
. 2022 Jun 14;S2468-0451(22)00028-1.
doi: 10.1016/j.idh.2022.05.006. Online ahead of print.
Predictors of mortality in patients with COVID-19 infection in different health-care settings: A retrospective analysis from a CORACLE study group
Lucio Boglione[SUP] 1 [/SUP], Silvia Corcione[SUP] 2 [/SUP], Nour Shbaklo[SUP] 3 [/SUP], Tommaso Lupia[SUP] 3 [/SUP], Silvia Scabini[SUP] 3 [/SUP], Simone Mornese Pinna[SUP] 3 [/SUP], Silvio Borrè[SUP] 4 [/SUP], Francesco Giuseppe De Rosa[SUP] 3 [/SUP]
Affiliations
Abstract
Background: Despite the large number of hospitalized patients affected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, few data are available about risk factors and mortality in subjects with nosocomially acquired respiratory infection of Coronavirus Disease 2019 (COVID-19).
Methods: We retrospectively evaluated in a multicentric study -during the pre-vaccination era-all patients admitted with confirmed diagnosis of nosocomial COVID-19 (NC). Patients were classified according to provenance: hospital-acquired NC or long-term care (LTC) facilities.
Results: Among overall 1047 patients evaluated with COVID-19, 137 had a confirmed diagnosis of NC (13%). 78 (56.9%) patients had hospital-acquired NC and 59 (43%) had LTC NC. Overall mortality was 35.8%, in hospital-acquired NC 24.4%, in LTC NC 50.8% (p < 0.001) (Log Rank test: p = 0.001). Timing of diagnosis was significantly different between hospital acquired and LTC NC (3.5 vs 10 days, p < 0.001). In multivariate analysis age, intensive-care unit admission, LTC provenance and sepsis were significant predictors of mortality in patients with NC infection.
Conclusion: Patients with NC are at higher risk of mortality (especially for LTC NC) and required preventive strategies, early diagnosis, and treatment to avoid COVID-19 cluster.
Keywords: COVID-19; Hospital infection; Long-term care; Mortality; Nosocomial; SARS-CoV-2.
. 2022 Jun 14;S2468-0451(22)00028-1.
doi: 10.1016/j.idh.2022.05.006. Online ahead of print.
Predictors of mortality in patients with COVID-19 infection in different health-care settings: A retrospective analysis from a CORACLE study group
Lucio Boglione[SUP] 1 [/SUP], Silvia Corcione[SUP] 2 [/SUP], Nour Shbaklo[SUP] 3 [/SUP], Tommaso Lupia[SUP] 3 [/SUP], Silvia Scabini[SUP] 3 [/SUP], Simone Mornese Pinna[SUP] 3 [/SUP], Silvio Borrè[SUP] 4 [/SUP], Francesco Giuseppe De Rosa[SUP] 3 [/SUP]
Affiliations
- PMID: 35750606
- PMCID: PMC9192942
- DOI: 10.1016/j.idh.2022.05.006
Abstract
Background: Despite the large number of hospitalized patients affected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, few data are available about risk factors and mortality in subjects with nosocomially acquired respiratory infection of Coronavirus Disease 2019 (COVID-19).
Methods: We retrospectively evaluated in a multicentric study -during the pre-vaccination era-all patients admitted with confirmed diagnosis of nosocomial COVID-19 (NC). Patients were classified according to provenance: hospital-acquired NC or long-term care (LTC) facilities.
Results: Among overall 1047 patients evaluated with COVID-19, 137 had a confirmed diagnosis of NC (13%). 78 (56.9%) patients had hospital-acquired NC and 59 (43%) had LTC NC. Overall mortality was 35.8%, in hospital-acquired NC 24.4%, in LTC NC 50.8% (p < 0.001) (Log Rank test: p = 0.001). Timing of diagnosis was significantly different between hospital acquired and LTC NC (3.5 vs 10 days, p < 0.001). In multivariate analysis age, intensive-care unit admission, LTC provenance and sepsis were significant predictors of mortality in patients with NC infection.
Conclusion: Patients with NC are at higher risk of mortality (especially for LTC NC) and required preventive strategies, early diagnosis, and treatment to avoid COVID-19 cluster.
Keywords: COVID-19; Hospital infection; Long-term care; Mortality; Nosocomial; SARS-CoV-2.