tetano
Editor, Senior Moderator
Oncotarget. 2015 Dec 23. doi: 10.18632/oncotarget.6746. [Epub ahead of print]
[h=1]Ineffectiveness of the 2014-2015 H3N2 influenza vaccine.[/h] Mandelboim M[SUP]1[/SUP], Glatman-Freedman A[SUP]2,[/SUP][SUP]3[/SUP], Drori Y[SUP]1[/SUP], Sherbany H[SUP]1[/SUP], Pando R[SUP]1[/SUP], Sefty H[SUP]2[/SUP], Zadka H[SUP]2[/SUP], Shohat T[SUP]2,[/SUP][SUP]4[/SUP], Keller N[SUP]5,[/SUP][SUP]6[/SUP], Mendelson E[SUP]1,[/SUP][SUP]4[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] The seasonal influenza vaccine is currently the most effective preventive modality against influenza infection. Nasopharyngeal samples of vaccinated and non-vaccinated patients presenting with Influenza-like-illness (ILI) were collected from over 20 outpatient clinics located in different geographic parts of Israel and were tested for the presence of influenza viruses (influenza A and influenza B). Here we show, that in the 2014-2015 season, the vaccine that included the A/Texas/50/2012 H3N2 virus was ineffective. Significant numbers of individuals vaccinated with the 2014-2015 vaccine, of all ages, were infected with influenza A (H3N2), manifesting similar symptoms as the non-vaccinated group. We further demonstrate that the Israeli circulating influenza A(H3N2) virus was different than that included in the 2014-2015 northern hemisphere vaccine, and that antibodies elicited by this vaccine were significantly less efficient in neutralizing influenza A(H3N2) infection.
[h=4]KEYWORDS:[/h] Immune response; Immunity; Immunology and Microbiology Section; influenza; vaccine
PMID: 26716420 [PubMed - as supplied by publisher] Free full text
[h=1]Ineffectiveness of the 2014-2015 H3N2 influenza vaccine.[/h] Mandelboim M[SUP]1[/SUP], Glatman-Freedman A[SUP]2,[/SUP][SUP]3[/SUP], Drori Y[SUP]1[/SUP], Sherbany H[SUP]1[/SUP], Pando R[SUP]1[/SUP], Sefty H[SUP]2[/SUP], Zadka H[SUP]2[/SUP], Shohat T[SUP]2,[/SUP][SUP]4[/SUP], Keller N[SUP]5,[/SUP][SUP]6[/SUP], Mendelson E[SUP]1,[/SUP][SUP]4[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] The seasonal influenza vaccine is currently the most effective preventive modality against influenza infection. Nasopharyngeal samples of vaccinated and non-vaccinated patients presenting with Influenza-like-illness (ILI) were collected from over 20 outpatient clinics located in different geographic parts of Israel and were tested for the presence of influenza viruses (influenza A and influenza B). Here we show, that in the 2014-2015 season, the vaccine that included the A/Texas/50/2012 H3N2 virus was ineffective. Significant numbers of individuals vaccinated with the 2014-2015 vaccine, of all ages, were infected with influenza A (H3N2), manifesting similar symptoms as the non-vaccinated group. We further demonstrate that the Israeli circulating influenza A(H3N2) virus was different than that included in the 2014-2015 northern hemisphere vaccine, and that antibodies elicited by this vaccine were significantly less efficient in neutralizing influenza A(H3N2) infection.
[h=4]KEYWORDS:[/h] Immune response; Immunity; Immunology and Microbiology Section; influenza; vaccine
PMID: 26716420 [PubMed - as supplied by publisher] Free full text