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Indonesia ready to use its own anti-bird flu vaccines

Sally Furniss

Well-known member
Indonesia ready to use its own anti-bird flu vaccines

http://english.people.com.cn/90001/90781/6276694.html

Indonesia, the hardest-hit by bird flu, has been ready to use its own anti-bird flu vaccines on human, after the country completed its clinical test, Health Minister Siti Fadilah Supari said in Jakarta Wednesday.

Minister Fadilah ensured that a priority would be given to the area which had suffered human clusters on avian influenza.

But, she said that a calculation was still needed to determine in detail how to use over 2 million doses vaccines that it has produced in cooperation with the U.S.-based drug maker Baxter.

The minister said that the clinical test of the vaccines was already complete in September.

"The vaccines are valid, (they) can be used now," she told Xinhua at the State Palace here.

Some parameters and rules for the application of the vaccines would be made soon, said Fadilah.

"We still need some approaches. We need to make calculation again," she said.

The health authorities would observe and watch closely which area was proper to be prioritized for using the vaccines, said Fadilah.

She said Karo regency in North Sumatra province would have the priority because it suffered bird flu cluster in April last year, and eight people were killed.

H5N1 virus spread from human-to-human between a small number of people within a family in the province. Indonesia declared the cluster as limited human-to-human transmission.

The cluster also occurred in Tanggerang, an outskirt city of the country's capital of Jakarta.

Indonesia has decided to use its own vaccines directly, ignoring the suggestion of the World Health Organization (WHO) to stockpile the vaccines and be used when a pandemic occur.

So far, the viruses have killed globally 196 out of 324 infected people, most of them in Indonesia with 86 fatalities and 107 cases.

Experts fear that the highly pathogenic H5N1 virus could mutate in a certain level that can make them transmittable among humans that can cause a pandemic where millions of people can be killed.

Huge territory, traditional way of rising chickens on back yard and lack of obedience of provincial administration in implementing the Jakarta decision to stop the virus spread, are among the obstacles in fighting the bird flu in the country.

Source: Xinhua
 
Re: Indonesia ready to use its own anti-bird flu vaccines

they think, the virus is still in Karo ?

The Karo-virus was much different from the Jakarta virus, so what
strain do they target with the vaccine ?
 
Re: Indonesia ready to use its own anti-bird flu vaccines

"... over 2 million doses vaccines that it has produced in cooperation with the U.S.-based drug maker Baxter. ... The health authorities would observe and watch closely which area was proper to be prioritized for using the vaccines, said Fadilah. ... She said Karo regency in North Sumatra province would have the priority because it suffered bird flu cluster in April last year, and eight people were killed."

If the upper text is exact, than:
they think, the virus is still in Karo ?
They didn' want to say, or they don't know exactly.
The Karo-virus was much different from the Jakarta virus, so what
strain do they target with the vaccine ?
If Karo would have the priority, than the target must be the Karo strain...
The exact answer must be easy to obtain: an response from the U.S.-based drug maker Baxter..., or some of the FluTrackers members, maybe?
 
Re: Indonesia ready to use its own anti-bird flu vaccines

the Karo-virus only appeared once, while the Java-viruses
reappear often and are similar to -say- A/IDN/5/05,
the WHO-recommended vaccine strain.
 
Re: Indonesia ready to use its own anti-bird flu vaccines

the Karo-virus only appeared once, while the Java-viruses
reappear often and are similar to -say- A/IDN/5/05,
the WHO-recommended vaccine strain.
Is it possible that this AH5N1 vaccine is an polivalent one
(few diff. sub-strains included)?
 
Re: Indonesia ready to use its own anti-bird flu vaccines

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Re: Indonesia ready to use its own anti-bird flu vaccines
<HR style="COLOR: #cccccc" SIZE=1><!-- / icon and title --><!-- message -->the Karo-virus only appeared once, while the Java-viruses
reappear often and are similar to -say- A/IDN/5/05,
the WHO-recommended vaccine strain.

</TD></TR></TBODY></TABLE>

But: "Re: Indonesia ready to use its own anti-bird flu vaccines",
and if they stated realy:
said Fadilah. ... She said Karo regency in North Sumatra province would have the priority... over 2 million doses vaccines that it has produced in cooperation with the U.S.-based drug maker Baxter.

Than they "must?" have a vaccine analog to "Karo strain".
Wouldn't be easer that FT ask "Baxter" to release an statement about?
Or it is classified Company info?

I saw an Dr. Niman post text at another FT thread, that corroborate the "Karo vacc. version" speculation:

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Resident

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Posts: 7,764



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Re: INDONESIA - Human cases - Sept 3 + </I>
<HR style="COLOR: #cccccc" SIZE=1><!-- / icon and title --><!-- message -->Quote:
<TABLE cellSpacing=0 cellPadding=6 width="100%" border=0><TBODY><TR><TD class=alt2 style="BORDER-RIGHT: 1px inset; BORDER-TOP: 1px inset; BORDER-LEFT: 1px inset; BORDER-BOTTOM: 1px inset">Originally Posted by Commonground
Dr. Niman, why would they have a priority here if it occured so long ago, and the virus is constantly changing - unless they are basing it on a genetics?

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There are two distinct clade 2.1 subclades in humans in Indonesia. Most have the novel cleavage site (RESRRKKR), and the vaccine being generated by WHO is against the first reported clade 2.1 human isolate (from a patient who died in the summer of 2005). In contrast, the Karo cluster (spring of 2006) had the consensus cleavage site found elsewhere (RERRRKKR), incluing the H5N1 in Indonesian swine. Karo was clearly H2H2H, so it is a reasonable target.

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Re: Indonesia ready to use its own anti-bird flu vaccines

Indonesia may have vaccinated many chickens & ducks, but let's not forget that 20% of the cats carry H5N1. :rolleyes:

I'd be worried about the Karo cats.

.
 
Re: Indonesia ready to use its own anti-bird flu vaccines

this is not the official version, however
 
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