Indonesia - Genetic Factors Can Increase the Likelihood of Contracting Bird Flu - Ivo Claassen

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Thursday, October 20, 2011 | 2:43 pm
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Combustion of poultry and cage, in order handling the bird flu outbreak in Indonesia. )

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If the deceased lived in one environment but not blood related we should worry

Although there is no evidence of transmission from human to human, genetic factors can increase the likelihood of contracting bird flu.

This was stated by Ivo Claassen, head of project office operations in the Indonesian-Dutch Partnership Programme on Highly Pathogenic Avian Influenza Control (IDP-HPAI), in Jakarta, Wednesday (19/10).

Recently, two brothers from Bangli, Bali died shortly after positive bird flu infection. Their mother, Ni Wayan Purnami, died shortly thereafter have not been identified although the main cause of his death.

According to Ivo, when some people have in common genenik, most likely they share the same weakness for contracting certain viruses. "I think the case in Bali is not transmitted from human to human, but they likely have vulnerabilities similar to bird flu because they are one family," said Ivo.

According to Ivo in Indonesia has several times occurred the victim died of bird flu was still a family.

:magnify:"If there is a cluster of cases of bird flu but still a family, it's very reasonable, but if the deceased lived in one environment but not blood related we should worry," he cautioned. :tiphat:http://translate.googleusercontent....g.html&usg=ALkJrhhQv65ZAPQYgh5Y5uoa3t1lD0nhVg

 

[Treyfish]

Re: Indonesia - Genetic Factors Can Increase the Likelihood of Contracting Bird Flu - Ivo Claassen

Study finds larger households a risk in Indonesian H5N1 clusters

Cluster outbreaks of H5N1 avian influenza (AI) in Indonesia involved larger households and more close relatives compared with isolated cases, according to a statistical analysis published in Clinical Infectious Diseases.

An international team of researchers analyzed data from 139 H5N1 outbreaks, of which 113 involved isolated cases and 26 were clusters. The outbreaks involved 177 total cases?159 laboratory confirmed and 18 probable. A cluster was defined as two or more cases associated with a specific setting, with disease onset within 2 weeks of each other. The average cluster size was 2.5 cases.

The team used logistic regression to assess risk factors for the outbreaks and found that clusters involved larger households and more blood-related contacts, especially first-degree relatives, compared with isolated cases. Risk factors for secondary case infection were being from 5 to 17 years old or 18 to 30, having direct exposure to sources of H5N1 virus, and being a first-degree relative of an index case. In fact, siblings were five times more likely to contract secondary cases than were other contacts. The authors conclude, "The study adds evidence that AI H5N1 infection is influenced by, and may even depend on, host genetic susceptibility."
Oct 19 Clin Infect Dis abstract :tiphat:http://www.cidrap.umn.edu/cidrap/content/influenza/avianflu/news/oct2011fluscan.html