Some research from Indonesia...
Some research from Indonesia...
toggletext-ed from Indonesian:
LIPI developed the Compound Just hindered Bird Flu
Jan 5, 2007
Jakarta (ANTARA News) - LIPI developed the new compound to hinder the activity of the spreading of the virus Avian influenza/AI (bird flu) that came from the biological diversity local.
"Uptil now inhibitor (the obstacle) AI protein uses the chemical from overseas, now we wanted to look for his replacement from the biological diversity local we ourselves," said the Researcher Puslit Biotechnology, Dr Ines Irene Atmosoekarto, that was contacted in Cibinong, on Friday.
Although having several alternatives to medicine for the virus threat H5N1 that was available in the market, according to him, can not satisfy the requirement for the market if being used the scenario pandemik influenza.
"The company that produced AI medicine not would strong supplied medicine if the AI virus has attacked properly common influenza that attacked from the person to the person. Moreover at this time the AI virus has shown the sign of resistance against this medicine," he said.
The search for the new reference molecule to hinder the AI virus needed the screening system/the effective and efficient screening, he said, and the molecule approach enabled the focus to the certain protein molecule by using the screening system.
This research, continued he, aimed at developing the screening procedure with the focus of protein M2 (the protein matrix 2) from the AI virus, where protein M2 was membrane protein from the influenza virus that his activity absolute was needed for the increase in the virus.
"In the influenza virus, there were the H element and N where between the outside membrane and in having the connector (M2) that if disumbat will hinder the development of the virus. This obstacle that will be looked for by us his compound," he said.
Inhibitor protein M2, said Ines, was known was the target that could be relied on to hinder the influenza virus. Moreover similar protein in the other virus for example Vpu (the HIV virus) and p7 (the C hepatitis virus) was the target that could be developed technically that was same.
The "principle" of the "screening, when M2 was forced entered the bacteria
[virus, probably], then the bacteria to was toxic. On the other hand if being put inhibitor (the obstacle - Ed.) protein M2, then the growth of the bacteria became good," he said.
The screening method tervalidasi this, said Ines, was developed to identify the new reference molecule the origin keanekargaman biological Indonesia that it was hoped could hinder the work of protein from this virus.
Therefore will be gotten the molecule that had the specific activity with the available raw material in the country and could be developed by the local pharmacy industry.
His side currently has prepared around 4.000 microbe extracts to be tested as the obstacle compound to AI virus protein.
http://www.antara.co.id/seenws/?id=50222