tetano
Editor, Senior Moderator
Indian J Med Microbiol
. Jul-Dec 2020;38(3 & 4):415-420.
doi: 10.4103/ijmm.IJMM_20_169.
Characteristics and outcomes of critically ill patients with influenza A (H1N1) in the Western Balkans during the 2019 post-pandemic season
Pedja Kovacevic[SUP] 1 [/SUP], Jovan Matijasevic[SUP] 2 [/SUP], Sasa Dragic[SUP] 3 [/SUP], Biljana Zlojutro[SUP] 3 [/SUP], Srdjan Gavrilovic[SUP] 2 [/SUP], Milka Jandric[SUP] 3 [/SUP], Ana Andrijevic[SUP] 2 [/SUP], Tijana Kovacevic[SUP] 4 [/SUP], Vladimir Carapic[SUP] 2 [/SUP], Maja Travar[SUP] 5 [/SUP], Ljubisa Preradovic[SUP] 6 [/SUP], Danica Momcicevic[SUP] 3 [/SUP]
Affiliations
Abstract
Background: This study looked at the characteristics and outcomes of critically ill patients with confirmed influenza A (H1N1) pdm09 infection in the Western Balkans in the post-pandemic period.
Materials and methods: This retrospective observational study of medical records and associated data collected during the post-pandemic period included all mechanically ventilated adult patients of two university-affiliated hospitals of the Western Balkans between 1 January and 31 March 2019 who had influenza A (H1N1) pdm09 infection confirmed by real-time reverse transcriptase-polymerase chain reaction from nasopharyngeal swab specimens and respiratory secretions.
Results: The study included 89 patients, 49 males (55.1%), aged 56.09 ? 12.64 years. The median time from shift from hospital time to intensive care unit was 1 day (range: 1-2). In the post-pandemic period, cases observed in this study were found to have the following comorbidities: cardiovascular diseases in 44 (49.4%) patients and diabetes in 21 (23.6%) patients. Thirty-one patients (34.8%) in this study were obese. All 89 patients (100%) experienced some degree of acute respiratory distress syndrome, and 39 (44%) had multiorgan failure. Eighty-three patients (93%) were intubated and mechanically ventilated, 6 (7%) received non-invasive mechanical ventilation, 12 (13%) were treated with vvECMO and 36 (40%) received renal replacement therapy. Vasoactive support was needed by 56 (63%) patients. The median duration of mechanical ventilation was 9 (6-15.5) days. The hospital mortality rate was 44%.
Conclusion: Critically ill patients with confirmed influenza A (H1N1) pdm09 infection in the post-pandemic season were older, required vasoactive drugs more often, and there was a trend of higher survival compared to H1N1 infection patients in the previous pandemic seasons.
Keywords: Acute respiratory distress syndrome; influenza A (H1N1) pdm09; mechanical ventilation; outcome.
. Jul-Dec 2020;38(3 & 4):415-420.
doi: 10.4103/ijmm.IJMM_20_169.
Characteristics and outcomes of critically ill patients with influenza A (H1N1) in the Western Balkans during the 2019 post-pandemic season
Pedja Kovacevic[SUP] 1 [/SUP], Jovan Matijasevic[SUP] 2 [/SUP], Sasa Dragic[SUP] 3 [/SUP], Biljana Zlojutro[SUP] 3 [/SUP], Srdjan Gavrilovic[SUP] 2 [/SUP], Milka Jandric[SUP] 3 [/SUP], Ana Andrijevic[SUP] 2 [/SUP], Tijana Kovacevic[SUP] 4 [/SUP], Vladimir Carapic[SUP] 2 [/SUP], Maja Travar[SUP] 5 [/SUP], Ljubisa Preradovic[SUP] 6 [/SUP], Danica Momcicevic[SUP] 3 [/SUP]
Affiliations
- PMID: 33154256
- DOI: 10.4103/ijmm.IJMM_20_169
Abstract
Background: This study looked at the characteristics and outcomes of critically ill patients with confirmed influenza A (H1N1) pdm09 infection in the Western Balkans in the post-pandemic period.
Materials and methods: This retrospective observational study of medical records and associated data collected during the post-pandemic period included all mechanically ventilated adult patients of two university-affiliated hospitals of the Western Balkans between 1 January and 31 March 2019 who had influenza A (H1N1) pdm09 infection confirmed by real-time reverse transcriptase-polymerase chain reaction from nasopharyngeal swab specimens and respiratory secretions.
Results: The study included 89 patients, 49 males (55.1%), aged 56.09 ? 12.64 years. The median time from shift from hospital time to intensive care unit was 1 day (range: 1-2). In the post-pandemic period, cases observed in this study were found to have the following comorbidities: cardiovascular diseases in 44 (49.4%) patients and diabetes in 21 (23.6%) patients. Thirty-one patients (34.8%) in this study were obese. All 89 patients (100%) experienced some degree of acute respiratory distress syndrome, and 39 (44%) had multiorgan failure. Eighty-three patients (93%) were intubated and mechanically ventilated, 6 (7%) received non-invasive mechanical ventilation, 12 (13%) were treated with vvECMO and 36 (40%) received renal replacement therapy. Vasoactive support was needed by 56 (63%) patients. The median duration of mechanical ventilation was 9 (6-15.5) days. The hospital mortality rate was 44%.
Conclusion: Critically ill patients with confirmed influenza A (H1N1) pdm09 infection in the post-pandemic season were older, required vasoactive drugs more often, and there was a trend of higher survival compared to H1N1 infection patients in the previous pandemic seasons.
Keywords: Acute respiratory distress syndrome; influenza A (H1N1) pdm09; mechanical ventilation; outcome.