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India- Has H1N1 virus mutated? Man on Tamiflu tests +ve

HenryN

Retired
<TABLE style="PADDING-LEFT: 10px" border=0 cellSpacing=0 cellPadding=0 width="100%"><TBODY><TR><TD vAlign=top width="100%">Has H1N1 virus mutated? Man on Tamiflu tests +ve</ARTTITLE>

4 Jul 2009, 0158 hrs IST, Pushpa Narayan, TNN
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</TD></TR><TR><TD vAlign=top align=left><!-- google_ad_section_start -->CHENNAI: The case of a 29-year-old man, who continued to remain H1N1 positive even after 2 week of treatment here, has doctors and health department officials in a tizzy. Experts fear that this could be an indication of the virus either having mutated or developed resistance to the anti-viral drug, Tamiflu. Mutation and drug resistance have been major challenges in dealing with viruses across the world. The present A(H1N1) is a strain developed from an earlier type which caused the Spanish flu.

What has added to the confusion in health circles here is that the man was discharged from the Communicable Diseases Hospital in Tondiarpet, where he was quarantined. Officials at the hospital said they had decided to discharge him based on a fax message they received from the National Institute of Communicable Diseases (NICD). ??Though his throat swabs continue to show positive, he was not showing any clinical symptoms. We told him not to step out of his residence for a week and advised him to stay away from the rest of his family members, particularly his pregnant wife,?? said Chennai corporation health officer, Dr B Kuganantham.

But the directorate of public health is panicky. ??We are upset that the NICD has directly contacted the hospital without keeping the government in the loop. The viral status of the patient is still positive, possibly because of a mutation or drug resistance. He could be a carrier who can spread the infection to other people,?? said director of public health Dr S Elango.


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http://timesofindia.indiatimes.com/articleshow/msid-4736094,prtpage-1.cms
 
Re: Has H1N1 virus mutated? Man on Tamiflu tests +ve

Re: Has H1N1 virus mutated? Man on Tamiflu tests +ve

<TABLE style="PADDING-LEFT: 10px" border=0 cellSpacing=0 cellPadding=0 width="100%"><TBODY><TR><TD vAlign=top width="100%">Has H1N1 virus mutated? Man on Tamiflu tests +ve</ARTTITLE>

4 Jul 2009, 0158 hrs IST, Pushpa Narayan, TNN

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</TD></TR><TR><TD vAlign=top align=left><!-- google_ad_section_start --> ??Though his throat swabs continue to show positive, he was not showing any clinical symptoms. We told him not to step out of his residence for a week and advised him to stay away from the rest of his family members, particularly his pregnant wife,?? said Chennai corporation health officer, Dr B Kuganantham.




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http://timesofindia.indiatimes.com/articleshow/msid-4736094,prtpage-1.cms
Asymptomatic, shedding virus, and Tamflu has no effect.
 
Re: India - H1N1 Tamiflu resistance suspected

Re: India - H1N1 Tamiflu resistance suspected

USA link


Possible case of ?resistant? A (H1N1) virus

Ramya Kannan

Positive tests, even after treatment, suggest a mutation

Blood sample to be sent to National Institute of Virology

CHENNAI: The Indian Council of Medical Research will investigate what seems to be a case of ?resistant? A (H1N1) virus in Chennai, its Director-General V. M. Katoch said. This is the first such case reported in the country.

The State health authorities have been asked to send a blood sample of the infected person to the National Institute of Virology (NIV), Pune.

The patient, a man who had flown in from the U.S. in the third week of June, had tested positive along with his wife.

They were quarantined at the Communicable Diseases Hospital (CDH) here and started on a course of Tamiflu. ?This was through the Directly Observed Treatment Short-course method, which means we know he took every tablet and did not miss out on even a single dose. Missing on doses can lead to resistance, but that is not the case with this patient,? Director of Public Health S. Elango said.

While his wife recovered and tested negative for A (H1N1) after about 10 days, the husband continued to test positive even after the treatment was completed.

Though he showed no symptoms, his tests kept coming back positive, Dr. Elango said.

?This is a case to be studied, definitely. The virus should not remain in his blood after the treatment. It is possible that it is a mutation of the virus. I have instructed the officials at the NIV to sequence the strain [from the samples] as soon as possible. Once we have that, we can have the alternative drugs to treat the patient,? Dr. Katoch explained.

He said the patient at the CDH could be treated on recommended doses of the drug ?Relenza? available in India.

When told that the patient was anxious to go home, Dr. Katoch categorically said that he could not be discharged as long as he continued to test positive, even if he was not symptomatic.

?He is certainly a carrier and can spread the virus to members of his family, and thereby take it into the community. That should not be allowed to happen. Indigenous transmission of the virus from this person will lead to a huge public health problem,? Dr. Katoch said.

The issue would be sorted out as soon as the sequence was drawn up. ?That way we will also be ready for any future occurrences.?

http://www.thehindu.com/2009/07/04/stories/2009070456041300.htm
 
Re: India - H1N1 Tamiflu resistance suspected

Re: India - H1N1 Tamiflu resistance suspected

and advised him to stay away from the rest of his family members, particularly his pregnant wife,??

That's it. :surrender:
 
Re: India - Has H1N1 virus mutated? Man on Tamiflu tests +ve

Re: India - Has H1N1 virus mutated? Man on Tamiflu tests +ve

Man on Tamiflu tests negative for H1N1, discharged from hospital

5 Jul 2009,

CHENNAI: Officials at the state health department heaved a sigh of relief on Saturday when they received a message from the National Institute of
Communicable Diseases, New Delhi, stating that a 29-year-old man who had remained positive for H1N1 virus despite being on Tamiflu treatment has tested negative.

He was discharged from the Communicable Diseases Hospital (CDS) here on Saturday.

Earlier, directorate of public health staff had expressed concerns when the man was discharged on Friday by CDH despite having remained positive for H1N1. He was brought back to the quarantine ward on Saturday and even his family members were instructed to start a course of anti-viral therapy to prevent infection.

Doctors were awaiting orders from the NICD on the further course of treatment for the patient - either another course of Tamiflu or another drug, Relenza.

"We are relieved that he is not a carrier anymore. He has been discharged. However, we have asked laboratories to investigate and let us know if there has been any mutation of the virus. We can't help the suspicion; it took him two courses of Tamiflu, against the normal one course, to recover," said director of public health Dr S Elango.

The man and his wife had arrived in Chennai airport on July 18. They were kept in quarantine at CDH after they showed symptoms of H1N1. Two days later, they were put on a course of Tamiflu treatment after laboratories confirmed they had tested positive for the viral infection.

They were given two 75 mg Tamiflu tablets, one in the morning and the other at night.

While the woman tested negative a week later, the man continued to be positive. He was then started on a second course of Tamiflu.


"We want to know why it took him so long to recover. It could be because of a mutation of the virus," Dr Elango said. The National Institute of Virology in Pune will now investigate why it took the patient almost a fortnight for recovery.

http://timesofindia.indiatimes.com/...charged-from-hospital/articleshow/4738884.cms
 
Re: India - Has H1N1 virus mutated? Man on Tamiflu tests +ve

Re: India - Has H1N1 virus mutated? Man on Tamiflu tests +ve

Is it standard practice, worldwide, to retest positive patients after they appear to have recovered?
 
Re: India - Has H1N1 virus mutated? Man on Tamiflu tests +ve

Re: India - Has H1N1 virus mutated? Man on Tamiflu tests +ve

Is it standard practice, worldwide, to retest positive patients after they appear to have recovered?
They are not discharged until they test negative.
 
Re: India - Has H1N1 virus mutated? Man on Tamiflu tests +ve

Re: India - Has H1N1 virus mutated? Man on Tamiflu tests +ve

There will be many cases of self administered tamiflu, especially here where tamiflu has been for sale over the counter. Many patients here have not been hospitalised either, after confirmation.
 
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