tetano
Editor, Senior Moderator
Influenza Other Respi Viruses. 2012 Apr 12. doi: 10.1111/j.1750-2659.2012.00364.x. [Epub ahead of print]
Increased reactions to pediatric influenza vaccination following concomitant pneumococcal vaccination.
Van Buynder PG, Frosst G, Van Buynder JL, Tremblay FW, Ross A, Jardine C, Fei BG.
Source
Fraser Health Authority, Surrey, British Columbia, Canada. University of Western Australia, Perth Western Australia, Australia. Simon Fraser University, Surrey, British Columbia, Canada. New Brunswick Department of Health, Fredericton NB Canada. Canadian Field Epidemiology Program, Public Health Agency of Canada, Ottawa ON. Canadian Institute for Health Information, Toronto, ON, Canada.
Abstract
Please cite this paper as: Van Buynder et al. (2012). Increased reactions to pediatric influenza vaccination following concomitant pneumococcal vaccination Influenza and Other Respiratory Viruses DOI: 10.1111/j.1750-2659.2012.00364.x. Background Influenza in children causes significant morbidity and hospitalizations and also some mortality particularly in children <5 years of age. Influenza vaccination in children has been shown to be safe and effective, but in 2010 the pediatric influenza vaccination program was suspended in Western Australia after the rate of febrile convulsions observed (9/1000 doses) was 55 times the previously reported rate. In 2009, over 80% of all children in New Brunswick were vaccinated with an adjuvanted monovalent H1N1 vaccine shown to have very high effectiveness, raising the prospect of potential hyper-responsiveness because of residual protection. We conducted enhanced post-marketing surveillance to monitor local and general reactions. Methods Parents of participating children seen at dedicated vaccination clinics were given influenza vaccine survey kits to record local and general symptoms up to 3 days following receipt of season influenza vaccine. Results Febrile reactions of ≥38? occurred in <10% of children who received a first dose of seasonal influenza vaccine (n = 660) and severe febrile incidents with fever ≥39? were uncommon. Concurrent administration of other vaccine(s) including conjugated pneumococcal vaccine appeared to increase reactogenicity. No child in the study had a febrile convulsion. Conclusion Influenza vaccines in children are safe, and this study provides a baseline for rapid assessment studies at the start of a vaccine season. Parents should be aware of increased fevers with concurrent vaccine administration, and antipyretics should be considered.
? 2012 Blackwell Publishing Ltd and Her Majesty the Queen in Right of Canada 2012. Reproduced with the permission of the Minister Health.
PMID:
22498052
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22498052
Increased reactions to pediatric influenza vaccination following concomitant pneumococcal vaccination.
Van Buynder PG, Frosst G, Van Buynder JL, Tremblay FW, Ross A, Jardine C, Fei BG.
Source
Fraser Health Authority, Surrey, British Columbia, Canada. University of Western Australia, Perth Western Australia, Australia. Simon Fraser University, Surrey, British Columbia, Canada. New Brunswick Department of Health, Fredericton NB Canada. Canadian Field Epidemiology Program, Public Health Agency of Canada, Ottawa ON. Canadian Institute for Health Information, Toronto, ON, Canada.
Abstract
Please cite this paper as: Van Buynder et al. (2012). Increased reactions to pediatric influenza vaccination following concomitant pneumococcal vaccination Influenza and Other Respiratory Viruses DOI: 10.1111/j.1750-2659.2012.00364.x. Background Influenza in children causes significant morbidity and hospitalizations and also some mortality particularly in children <5 years of age. Influenza vaccination in children has been shown to be safe and effective, but in 2010 the pediatric influenza vaccination program was suspended in Western Australia after the rate of febrile convulsions observed (9/1000 doses) was 55 times the previously reported rate. In 2009, over 80% of all children in New Brunswick were vaccinated with an adjuvanted monovalent H1N1 vaccine shown to have very high effectiveness, raising the prospect of potential hyper-responsiveness because of residual protection. We conducted enhanced post-marketing surveillance to monitor local and general reactions. Methods Parents of participating children seen at dedicated vaccination clinics were given influenza vaccine survey kits to record local and general symptoms up to 3 days following receipt of season influenza vaccine. Results Febrile reactions of ≥38? occurred in <10% of children who received a first dose of seasonal influenza vaccine (n = 660) and severe febrile incidents with fever ≥39? were uncommon. Concurrent administration of other vaccine(s) including conjugated pneumococcal vaccine appeared to increase reactogenicity. No child in the study had a febrile convulsion. Conclusion Influenza vaccines in children are safe, and this study provides a baseline for rapid assessment studies at the start of a vaccine season. Parents should be aware of increased fevers with concurrent vaccine administration, and antipyretics should be considered.
? 2012 Blackwell Publishing Ltd and Her Majesty the Queen in Right of Canada 2012. Reproduced with the permission of the Minister Health.
PMID:
22498052
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22498052