tetano
Editor, Senior Moderator
The Journal of Infectious Diseases 2010;202:1634?1638
? 2010 by the Infectious Diseases Society of America. All rights reserved.
0022-1899/2010/20211-0004$15.00
DOI: 10.1086/657084
BRIEF REPORT
Inactivated Seasonal Influenza Vaccines Increase Serum Antibodies to the Neuraminidase of Pandemic Influenza A(H1N1) 2009 Virus in an Age‐Dependent Manner
Glendie Marcelin,1
Hilliary M. Bland,1,a
Nicholas J. Negovetich,1
Matthew R. Sandbulte,2
Ali H. Ellebedy,1
Ashley D. Webb,1
Yolanda S. Griffin,1,a
Jennifer L. DeBeauchamp,1
Janet E. McElhaney,3,4 and
Richard J. Webby1
1Department of Infectious Diseases, St Jude Children?s Research Hospital, Memphis, Tennessee; 2Division of Viral Products, Center for Biologics Evaluation and Research, United States Food and Drug Administration, Bethesda, Maryland; 3Department of Immunology, University of Connecticut School of Medicine, Farmington; 4Department of Medicine, University of British Columbia, Vancouver, Canada
Levels of preexisting antibodies to the hemagglutinin of pandemic influenza A(H1N1) 2009 (hereafter pandemic H1N1) virus positively correlate with age. The impact of contemporary seasonal influenza vaccines on establishing immunity to other pandemic H1N1 proteins is unknown. We measured serum antibodies to the neuraminidase (NA) of pandemic H1N1 in adults prior to and after vaccination with seasonal trivalent inactivated influenza vaccines. Serum antibodies to pandemic H1N1 NA were observed in all age groups; however, vaccination elevated levels of pandemic H1N1 NA antibodies predominately in elderly individuals (age, 60 years). Therefore, contemporary seasonal vaccines likely contribute to reduction of pandemic H1N1?associated disease in older individuals.
http://www.journals.uchicago.edu/doi/abs/10.1086/657084
? 2010 by the Infectious Diseases Society of America. All rights reserved.
0022-1899/2010/20211-0004$15.00
DOI: 10.1086/657084
BRIEF REPORT
Inactivated Seasonal Influenza Vaccines Increase Serum Antibodies to the Neuraminidase of Pandemic Influenza A(H1N1) 2009 Virus in an Age‐Dependent Manner
Glendie Marcelin,1
Hilliary M. Bland,1,a
Nicholas J. Negovetich,1
Matthew R. Sandbulte,2
Ali H. Ellebedy,1
Ashley D. Webb,1
Yolanda S. Griffin,1,a
Jennifer L. DeBeauchamp,1
Janet E. McElhaney,3,4 and
Richard J. Webby1
1Department of Infectious Diseases, St Jude Children?s Research Hospital, Memphis, Tennessee; 2Division of Viral Products, Center for Biologics Evaluation and Research, United States Food and Drug Administration, Bethesda, Maryland; 3Department of Immunology, University of Connecticut School of Medicine, Farmington; 4Department of Medicine, University of British Columbia, Vancouver, Canada
Levels of preexisting antibodies to the hemagglutinin of pandemic influenza A(H1N1) 2009 (hereafter pandemic H1N1) virus positively correlate with age. The impact of contemporary seasonal influenza vaccines on establishing immunity to other pandemic H1N1 proteins is unknown. We measured serum antibodies to the neuraminidase (NA) of pandemic H1N1 in adults prior to and after vaccination with seasonal trivalent inactivated influenza vaccines. Serum antibodies to pandemic H1N1 NA were observed in all age groups; however, vaccination elevated levels of pandemic H1N1 NA antibodies predominately in elderly individuals (age, 60 years). Therefore, contemporary seasonal vaccines likely contribute to reduction of pandemic H1N1?associated disease in older individuals.
http://www.journals.uchicago.edu/doi/abs/10.1086/657084