Inactivated North American And European H5N2 Avian Influenza Virus Vaccines Protect Chickens From Asian H5N1 High Pathongenicity Avian Influenza Virus

[Sally Furniss]

[FONT=verdana,arial,helvetica][SIZE=-1]INACTIVATED NORTH AMERICAN AND EUROPEAN H5N2 AVIAN INFLUENZA VIRUS VACCINES PROTECT CHICKENS FROM ASIAN H5N1 HIGH PATHOGENICITY AVIAN INFLUENZA VIRUS [/SIZE][/FONT] [FONT=verdana,arial][SIZE=-1]
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</td><td align="left" background="/incme/images/spacer.gif" valign="top">[FONT=verdana,arial][SIZE=-1] Swayne, David [/SIZE][/FONT]</td></tr> <tr><td valign="top">

</td><td align="left" background="/incme/images/spacer.gif" valign="top">[FONT=verdana,arial][SIZE=-1] Lee, Chang [/SIZE][/FONT]</td></tr> <tr><td valign="top">

</td><td align="left" background="/incme/images/spacer.gif" valign="top">[FONT=verdana,arial][SIZE=-1] Spackman, Erica [/SIZE][/FONT]</td></tr> </tbody></table>​

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<script> <!-- function showinfo(){ window.open('_pubinfo.js', 'pubinfo', 'height=150,width=150') pubinfo.document.write('hi

'); } // --> </script> Submitted to: Avian Pathology
<!--Publication type added 03-02-06 --> Publication Type: Peer Reviewed Journal
Publication Acceptance Date: November 28, 2006
Publication Date: April 1, 2006
<!--Removed abstract only flag 03-02-06 when pub_type_code was added to display --> <!-- --> <!-- To appease ARIS/NPS folks, the publisher's url that links to reprints hosted at ars.usda.gov were not displayed, as per PVL March 2006. We await the reprint field in ARIS --> <!-- Reprint URL field added to ARIS June 1, 2006, file modified June 6, 2006 --> <!-- June 6, 2006: To capture good data stored in the publisher's url field that links to a reprint uploaded in SP, the following clause is inserted to display that information as the 'reprint url' --> <!-- Edited Aug. 15, 2007 JCP to increase manuscript title comparison from 50 to 60 characters --> Citation: Swayne, D.E., Lee, C.W., Spackman, E. 2006. Inactivated North American and European H5N2 avian influenza virus vaccines protect chickens from Asian H5N1 high pathogenicity avian influenza virus. Avian Pathology. 35(2):141-146. Interpretive Summary: The deadly H5N1 high pathogenicity avian influenza (HPAI) virus has caused large death losses in birds within nine Asian countries/regions. Chickens vaccinated with two different H5N2 commercial AI vaccine strains were protected from a recent Asian H5N1 HPAI virus. The chickens were protected from illness and death, and the H5N1 virus grew in few birds. In addition, when the virus grew in vaccinated chickens, much less virus was produced than in non-vaccinated chickens. These data indicate that the currently available H5 vaccines will protect chickens against the Asian H5N1 HPAI virus should it enter the USA. Technical Abstract: High pathogenicity (HP) avian influenza (AI) of the H5N1 subtype has caused an unprecedented epizootic in birds within nine Asian countries/regions since first reported in 1996. Vaccination has emerged as a tool for use in managing the infection in view of future eradication. This study was undertaken to determine if two divergent H5N2 commercial vaccine strains, one based on a European and the other a North American low pathogenicity AI virus, could protect chickens against a recent Asian H5N1 HPAI virus. The North American and European vaccine viruses had 84% and 91% deduced amino acid sequence similarity to the HA1 segment of haemagglutinin protein of Indonesia H5N1 HPAI challenge virus, respectively. Both vaccine strains provided complete protection from clinical signs and death. The vaccines reduced the number of chickens infected and shedding virus from the respiratory and intestinal tracts. In addition, the quantity of virus shed was reduced by 104-5 mean embryo infectious doses (EID50). The use of specific neuraminidase inhibition tests allowed identification of infected chickens within the vaccinated groups. These data indicate that the currently available H5 vaccines of European and North American lineages will protect chickens against the Asian H5N1 HPAI virus and reduce environmental contamination by the H5N1 HPAI virus. They will be an adjunct to biosecurity measures to reduce virus transmission.


http://www.ars.usda.gov/research/publications/Publications.htm?seq_no_115=184663

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[Snowy Owl]

Re: INACTIVATED NORTH AMERICAN AND EUROPEAN H5N2 AVIAN INFLUENZA VIRUS VACCINES PROTECT CHICKENS FROM ASIAN H5N1 HIGH PATHOGENICITY AVIAN INFLUENZA VI

Re: INACTIVATED NORTH AMERICAN AND EUROPEAN H5N2 AVIAN INFLUENZA VIRUS VACCINES PROTECT CHICKENS FROM ASIAN H5N1 HIGH PATHOGENICITY AVIAN INFLUENZA VI

It could be a good news but having correlated datas with the following would be usefull.

Snowy

Weaker avian flu virus confirmed to change deadly


Japanese researchers have found that a weaker strain of the bird flu virus known as H5N2 can mutate into a deadly one through repeated infections.

http://www.nhk.or.jp/daily/english/03_19.html

Researchers led by Tottori University professor Toshihiro Ito successively infected chicks with the weaker H5N2 variant. The strain was taken from chickens at a poultry farm in Ibaraki Prefecture where the virus was detected in 2005.

The researchers found that the 28th batch of chicks all died after being infected with H5N2. Eight adult chickens injected with the virus also died after several days.

The researchers say the findings show that the weaker strain of the virus turned into a virulent one through repeated infections.

This is the first confirmed case of mutation of an avian flu virus collected from a domestic farm.

Starting in 2005, around 5.8 million chickens were destroyed in Ibaraki prefecture after an outbreak of avian flu caused by the H5N2 strain.

This measure drew criticism from some parties because few birds had died from the infection.

Professor Ito says the mutation occurred earlier than expected. He says the findings underscore the importance of containing any bird flu virus because there is no knowing what sort of mutation could occur at a poultry farm where tens of thousands of birds are kept.
2008/04/03 14:57

http://www.flutrackers.com/forum/showthread.php?t=62568&highlight=h5n2

 

[HenryN]

Re: Inactivated North American And European H5N2 Avian Influenza Virus Vaccines Protect Chickens From Asian H5N1 High Pathongenicity Avian Influenza V

Re: Inactivated North American And European H5N2 Avian Influenza Virus Vaccines Protect Chickens From Asian H5N1 High Pathongenicity Avian Influenza V

Mismatched vaccines drive H5N1 evolution. The results in Egypt are hard to ignore.

 

[JJackson]

Re: INACTIVATED NORTH AMERICAN AND EUROPEAN H5N2 AVIAN INFLUENZA VIRUS VACCINES PROTECT CHICKENS FROM ASIAN H5N1 HIGH PATHOGENICITY AVIAN INFLUENZA VI

Re: INACTIVATED NORTH AMERICAN AND EUROPEAN H5N2 AVIAN INFLUENZA VIRUS VACCINES PROTECT CHICKENS FROM ASIAN H5N1 HIGH PATHOGENICITY AVIAN INFLUENZA VI

This is the first confirmed case of mutation of an avian flu virus collected from a domestic farm.

H7N3 British Columbia 2004 LPAI went to HPAI in poultry sheds.

I would also argue there is a strong case to make for the emergence of the Fujian strain being at least partly a result of selection pressures applied by the Chinese poultry vaccination program.