tetano
Editor, Senior Moderator
Can J Vet Res. 2013 Jan;77(1):24-32.
In vivo evaluation of vaccine efficacy against challenge with a contemporary field isolate from the α cluster of H1N1 swine influenza virus.
Detmer SE, Gramer MR, King VL, Mathur S, Rapp-Gabrielson VJ.
Source
Veterinary Diagnostic Laboratory, University of Minnesota, College of Veterinary Medicine, 1333 Gortner Avenue, St. Paul, Minnesota 55108, USA (Detmer, Gramer); Veterinary Medicine Research and Development, Pfizer Animal Health, 7000 Portage Road, Kalamazoo, MI 49001, USA (King, Mathur, Rapp-Gabrielson).
Abstract
in English, French
Influenza A virus vaccines currently contain a mixture of isolates that reflect the genetic and antigenic characteristics of the currently circulating strains. This study was conducted to evaluate the efficacy of a trivalent inactivated swine influenza virus vaccine (Flusure XP) in pigs challenged with a contemporary α-cluster H1N1 field isolate of Canadian swine origin. Pigs were allocated to vaccinated, placebo, and negative-control groups and monitored for respiratory disease for 5 d after challenge. On the challenge day and 5 d after challenge the serum of the vaccinated pigs had reciprocal hemagglutination inhibition antibody titers 40 for all the vaccine viruses but ≤ 20 for the challenge virus. Gross lesions were present in the lungs of all pigs that had been inoculated with the challenge virus, but the proportion of lung tissue consolidated did not differ significantly between the placebo and vaccinated pigs. However, the amount of virus was significantly reduced in the nasal secretions, lungs, and bronchoalveolar lavage fluid in the vaccinated pigs compared with the placebo pigs. These results indicate that swine vaccinated with Flusure XP were partially protected against experimental challenge with a swine α-cluster H1N1 virus that is genetically similar to viruses currently circulating in Canadian swine.
PMID:
23814353
[PubMed - in process]
PMCID:
PMC3525169
http://www.ncbi.nlm.nih.gov/pubmed/23814353
In vivo evaluation of vaccine efficacy against challenge with a contemporary field isolate from the α cluster of H1N1 swine influenza virus.
Detmer SE, Gramer MR, King VL, Mathur S, Rapp-Gabrielson VJ.
Source
Veterinary Diagnostic Laboratory, University of Minnesota, College of Veterinary Medicine, 1333 Gortner Avenue, St. Paul, Minnesota 55108, USA (Detmer, Gramer); Veterinary Medicine Research and Development, Pfizer Animal Health, 7000 Portage Road, Kalamazoo, MI 49001, USA (King, Mathur, Rapp-Gabrielson).
Abstract
in English, French
Influenza A virus vaccines currently contain a mixture of isolates that reflect the genetic and antigenic characteristics of the currently circulating strains. This study was conducted to evaluate the efficacy of a trivalent inactivated swine influenza virus vaccine (Flusure XP) in pigs challenged with a contemporary α-cluster H1N1 field isolate of Canadian swine origin. Pigs were allocated to vaccinated, placebo, and negative-control groups and monitored for respiratory disease for 5 d after challenge. On the challenge day and 5 d after challenge the serum of the vaccinated pigs had reciprocal hemagglutination inhibition antibody titers 40 for all the vaccine viruses but ≤ 20 for the challenge virus. Gross lesions were present in the lungs of all pigs that had been inoculated with the challenge virus, but the proportion of lung tissue consolidated did not differ significantly between the placebo and vaccinated pigs. However, the amount of virus was significantly reduced in the nasal secretions, lungs, and bronchoalveolar lavage fluid in the vaccinated pigs compared with the placebo pigs. These results indicate that swine vaccinated with Flusure XP were partially protected against experimental challenge with a swine α-cluster H1N1 virus that is genetically similar to viruses currently circulating in Canadian swine.
PMID:
23814353
[PubMed - in process]
PMCID:
PMC3525169
http://www.ncbi.nlm.nih.gov/pubmed/23814353