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Antibiot Khimioter. 2010;55(5-6):32-5.
[In vivo efficacy of Ingavirin against pandemic A (H1N1/09)v influenza virus].
[Article in Russian]
[No authors listed]
Abstract
Ingavirin was shown to be efficient in inhibition of the pandemic influenza virus strains A/California/04/2009 (H1N1)v, A/California/07/2009 (H1N1)v, A/Moscow/225/2009 (H1N1)v and A/Moscow/226/2009 (H1N1)v. as well as the influenza virus strain A/Aichi/2/68 (H3N2) in the lungs of the infected mice. After oral administration of Ingavirin the titers of the influenza virus strains in the lung homogenates lowered.
Re: In vivo efficacy of Ingavirin against pandemic A (H1N1/09)v influenza virus
Antibiot Khimioter. 2010;55(5-6):24-31.
[Protective activity of Ingavirin in experimental lethal influenza due to pandemic influenza virus A (H1N1)v (albino mice)].
[Article in Russian]
[No authors listed]
Abstract
Despite obvious success in the vaccine development and chemotherapy of influenza, it remains a poorly controlled infection leading to emergence of new pandemic variants of the virus with high morbidity and mortality. We investigated the protective activity of Ingavirin against the lethal influenza A (H1N1) 2009 virus infection on albino mice. Oral use of Ingavirin resulted in sharp decreasing of the mortality (index of protection up to 57%), slight decreasing of the infectious titer of the virus in the lungs (up to 40-fold), normalizing of the body weight dynamics and the lung tissue structure vs. the placebo-treated control. The degree of the bronchial epithelium damage was also strongly decreased. The results allow to consider Ingavirin as an effective antiviral against the current pandemic influenza virus.
