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In vitro selection of electrochemical peptide probes using bioorthogonal tRNA for influenza virus detection

tetano

Editor, Senior Moderator
Chem Commun (Camb). 2018 May 2. doi: 10.1039/c8cc01775a. [Epub ahead of print]
[h=1]In vitro selection of electrochemical peptide probes using bioorthogonal tRNA for influenza virus detection.[/h] K C TB[SUP]1[/SUP], Tada S[SUP]2[/SUP], Zhu L[SUP]3[/SUP], Uzawa T[SUP]4[/SUP], Minagawa N[SUP]5[/SUP], Luo SC[SUP]6[/SUP], Zhao H[SUP]7[/SUP], Yu HH[SUP]8[/SUP], Aigaki T[SUP]9[/SUP], Ito Y[SUP]10[/SUP].
[h=3]Author information[/h]

[h=3]Abstract[/h] An electrosensitive peptide probe has been developed from an in vitro selection technique using biorthogonal tRNA prepared with an electroreactive non-natural amino acid, 3,4-ethylenedioxythiophene-conjugated aminophenylalanine. The selected probe quantitatively detected the influenza virus based on a signal "turn-on" mechanism. The developed strategy could be used to develop electrochemical biosensors toward a variety of targets.


PMID: 29718049 DOI: 10.1039/c8cc01775a
 
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