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In Singapore, a rare contamination Two cases of transfusional dengue

Francoise Ramona

Well-known member
In Singapore, a rare contamination Two cases of transfusional dengue

Traduction machine

On July 15, 2007, a 52 year old Singaporean carried out a blood donation. Parce qu' it had a fever the following day and qu' he had been already sensitized with the infectious risks of the gift, being usual donor, he informed his manifold centre which immediately set up procedures of traceability of the blood products.

One analyzed by PCR has d' shown access that the donor was carrying d' a virus of the dengue of the type 2, a frequent infection in Singapore, where Aedes aegypti, the vector, is endemic.

The globular base resulting from the gift was transfused with a 72 year old man polypathologic who presented 48 hours later an associating table of the fever, myalgias and a feeling d' asthenia. Blood testings confirmed the presence of the virus. Another patient, 64 years, which received frozen plasma has, for its part, presented a fever, a ict?re and a fall of its rate of plates. The biological analyses also confirmed the presence of the virus whose genome was perfectly superposable with that of the two other patients. Lastly, a 74 year old man who suffered d' carcinome h?patocellulaire and which received the plates of the donor n' presented no clinical sign and the biological examinations confirmed an absence of seroconversion. L' equip with Dr. Paul Tambyah (Singapore) stresses that the transfusional dengues are very rare. They propose that, in the countries d' end?mie, of the specific tests are applied to all the blood donations in order to limit the transmission risk of the disease which can be severe among high-risk patients. > Dr. I.C.
?New England Journal off Medicine?, vol. 359; 14: 1526-1527, October 2, 2008.



? Singapour, une contamination rare

Deux cas de dengue transfusionnelle



LE 15 JUILLET 2007, un Singapourien de 52 ans a effectu? un don de sang. Parce qu'il a pr?sent? une fi?vre le lendemain et qu'il avait ?t? d?j? sensibilis? aux risques infectieux du don, ?tant donneur habituel, il a inform? son centre de collecte qui a imm?diatement mis en place des proc?dures de tracabilit? des produits sanguins.
Une analys? par PCR a d'abord montr? que le donneur ?tait porteur d'un virus de la dengue de type 2, un infection fr?quente ? Singapour, o? Aedes aegypti, le vecteur, est end?mique.
Le culot globulaire r?sultant du don a ?t? transfus? ? un homme de 72 ans polypathologique qui a pr?sent? 48 heures plus tard un tableau associant de la fi?vre, des myalgies et une sensation d'asth?nie. Les tests sanguins ont confirm? la pr?sence du virus. Un autre patient, de 64 ans, qui a re?u le plasma congel? a, pour sa part, pr?sent? une fi?vre, un ict?re et une baisse de son taux de plaquettes. Les analyses biologiques ont aussi confirm? la pr?sence du virus dont le g?nome ?tait parfaitement superposable ? celui des deux autres patients. Enfin, un homme de 74 ans qui souffrait d'un carcinome h?patocellulaire et qui a re?u les plaquettes du donneur n'a pr?sent? aucun signe clinique et les examens biologiques ont confirm? une absence de s?roconversion. L'?quipe du Dr Paul Tambyah (Singapour) souligne que les dengues transfusionnelles sont tr?s rares. Ils proposent que, dans les pays d'end?mie, des tests sp?cifiques soient appliqu?s ? tous les dons de sang afin de limiter le risque de transmission de la maladie qui peut ?tre s?v?re chez les patients ? haut risque.

> Dr I. C.

? New England Journal of Medicine ?, vol. 359 ; 14 : 1526-1527, 2 octobre 2008.


http://www.quotimed.com/journal/index.cfm?fuseaction=viewarticle&DartIdx=416613
 
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