In-Depth: Can a simple technique during COVID vaccination stop myocarditis?

[Emily]

If we don't benefit from research like this, then the animals are being tortured for no reason.

https://www.10news.com/news/in-dept...ique-stop-myocarditis-after-covid-vaccination
In-Depth: Can a simple technique during COVID vaccination stop myocarditis?

Derek Staahl

Posted at 7:56 PM, Sep 30, 2021
and last updated 2021-09-30 23:26:14-04

SAN DIEGO (KGTV) -- Some newly published research suggests the rare cases of heart inflammation linked to the COVID-19 vaccines might be caused by an accidental injection in the wrong spot.
All of the authorized vaccines are designed to be injected into a muscle, not a blood vessel.
Research published in the journal Clinical Infectious Diseases in August found mice injected with mRNA into a vein developed heart inflammation, called myopericarditis. Mice injected in the proper location, the muscle, did not...

 

[sharon sanders]

Intravenous Injection of Coronavirus Disease 2019 (COVID-19) mRNA Vaccine Can Induce Acute Myopericarditis in Mouse Model


Can Li, Yanxia Chen, Yan Zhao, David Christopher Lung, Zhanhong Ye, Wenchen Song, Fei-Fei Liu, Jian-Piao Cai, Wan-Man Wong, Cyril Chik-Yan Yip ... Show more
Author Notes
Clinical Infectious Diseases, ciab707, https://doi.org/10.1093/cid/ciab707
Published:

18 August 2021

Abstract

Background

Post-vaccination myopericarditis is reported after immunization with coronavirus disease 2019 (COVID-19) messenger RNA (mRNA) vaccines. The effect of accidental intravenous injection of this vaccine on the heart is unknown.

Methods

We compared the clinical manifestations, histopathological changes, tissue mRNA expression, and serum levels of cytokine/chemokine in Balb/c mice at different time points after intravenous (IV) or intramuscular (IM) vaccine injection with normal saline (NS) control.

Results

Although significant weight loss and higher serum cytokine/chemokine levels were found in IM group at 1–2 days post-injection (dpi), only IV group developed histopathological changes of myopericarditis as evidenced by cardiomyocyte degeneration, apoptosis, and necrosis with adjacent inflammatory cell infiltration and calcific deposits on visceral pericardium, although evidence of coronary artery or other cardiac pathologies was absent. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike antigen expression by immunostaining was occasionally found in infiltrating immune cells of the heart or injection site, in cardiomyocytes and intracardiac vascular endothelial cells, but not skeletal myocytes. The histological changes of myopericarditis after the first IV-priming dose persisted for 2 weeks and were markedly aggravated by a second IM- or IV-booster dose. Cardiac tissue mRNA expression of interleukin (IL)-1β, interferon (IFN)-β, IL-6, and tumor necrosis factor (TNF)-α increased significantly from 1 dpi to 2 dpi in the IV group but not the IM group, compatible with presence of myopericarditis in the IV group. Ballooning degeneration of hepatocytes was consistently found in the IV group. All other organs appeared normal.

Conclusions

This study provided in vivo evidence that inadvertent intravenous injection of COVID-19 mRNA vaccines may induce myopericarditis. Brief withdrawal of syringe plunger to exclude blood aspiration may be one possible way to reduce such risk.

https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciab707/6353927

 

[sharon sanders]

bump this