tetano
Editor, Senior Moderator
Crit Rev Microbiol. 2015 Mar 26:1-8. [Epub ahead of print]
[h=1]Importance of interferon inducible trans-membrane proteins and retinoic acid inducible gene I for influenza virus replication: A review.[/h] Suo S[SUP]1[/SUP], Ren X.
[h=3]Author information[/h]
[h=3]Abstract[/h] Understanding the interplay between Influenza viruses and host cells is key to elucidating the pathogenesis of these viruses. Several host factors have been identified that exert antiviral functions; however, influenza viruses continue to replicate utilizing host cell machinery. Herein, we review the mechanisms of action of two host-derived proteins on conferring cellular resistance to the influenza virus; (1) the interferon inducible trans-membrane proteins, 1, 2 and 3, a recently identified family of early restriction factors; and (2) retinoic acid inducible gene I, a key mediator of antiviral immunity. These data may contribute to the design of novel and efficient anti-influenza treatments.
[h=4]KEYWORDS:[/h] Antiviral immunity; influenza virus; signal pathway
PMID: 25811941 [PubMed - as supplied by publisher]
[h=1]Importance of interferon inducible trans-membrane proteins and retinoic acid inducible gene I for influenza virus replication: A review.[/h] Suo S[SUP]1[/SUP], Ren X.
[h=3]Author information[/h]
[h=3]Abstract[/h] Understanding the interplay between Influenza viruses and host cells is key to elucidating the pathogenesis of these viruses. Several host factors have been identified that exert antiviral functions; however, influenza viruses continue to replicate utilizing host cell machinery. Herein, we review the mechanisms of action of two host-derived proteins on conferring cellular resistance to the influenza virus; (1) the interferon inducible trans-membrane proteins, 1, 2 and 3, a recently identified family of early restriction factors; and (2) retinoic acid inducible gene I, a key mediator of antiviral immunity. These data may contribute to the design of novel and efficient anti-influenza treatments.
[h=4]KEYWORDS:[/h] Antiviral immunity; influenza virus; signal pathway
PMID: 25811941 [PubMed - as supplied by publisher]