tetano
Editor, Senior Moderator
J Infect Dis. 2014 May 1. [Epub ahead of print]
Impact of Body Mass Index on Immunogenicity of Pandemic H1N1 Vaccine in Children and Adults.
Callahan ST1, Wolff M, Hill HR, Edwards KM; on behalf of the NIAID Vaccine and Treatment Evaluation Unit (VTEU) Pandemic H1N1 Vaccine Study Group.
Author information
Abstract
Obesity emerged as a risk factor for morbidity and mortality related to 2009 pandemic influenza A (H1N1) infection. However, few studies examine the immune responses to H1N1 vaccine among children and adults of various body mass indices (BMI). Pooling data from three trials of unadjuvanted split-virus H1N1 A/California/07/2009 influenza vaccines, we analyzed serologic responses of participants stratified by BMI grouping. A single vaccine dose produced higher hemagglutination inhibition antibody titers at day 21 in obese compared to non-obese adults, but there were no significant differences in responses to H1N1 vaccine among children or adults of various BMI following two doses.
PMID:
24795475
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24795475
Impact of Body Mass Index on Immunogenicity of Pandemic H1N1 Vaccine in Children and Adults.
Callahan ST1, Wolff M, Hill HR, Edwards KM; on behalf of the NIAID Vaccine and Treatment Evaluation Unit (VTEU) Pandemic H1N1 Vaccine Study Group.
Author information
Abstract
Obesity emerged as a risk factor for morbidity and mortality related to 2009 pandemic influenza A (H1N1) infection. However, few studies examine the immune responses to H1N1 vaccine among children and adults of various body mass indices (BMI). Pooling data from three trials of unadjuvanted split-virus H1N1 A/California/07/2009 influenza vaccines, we analyzed serologic responses of participants stratified by BMI grouping. A single vaccine dose produced higher hemagglutination inhibition antibody titers at day 21 in obese compared to non-obese adults, but there were no significant differences in responses to H1N1 vaccine among children or adults of various BMI following two doses.
PMID:
24795475
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24795475