tetano
Editor, Senior Moderator
Braz J Infect Dis. 2018 Jun 4. pii: S1413-8670(17)31049-8. doi: 10.1016/j.bjid.2018.05.004. [Epub ahead of print]
[h=1]Impact of A/H1N1 influenza in children at a Brazilian University Hospital.[/h] Biondo GF[SUP]1[/SUP], Santana JC[SUP]2[/SUP], Lago PM[SUP]2[/SUP], Piva J[SUP]2[/SUP], Souza PRA[SUP]3[/SUP], Gaulke JG[SUP]3[/SUP], Sebben JM[SUP]4[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] A/H1N1 influenza is a viral disease that affects a significant part of the population mainly in winter, leading to increased number of medical consultations, hospitalizations and consequently care spending in emergency.
[h=4]METHODS:[/h] This is a case-series retrospective study, involving patients admitted to a tertiary hospital in southern Brazil in 2016 with a clinical diagnosis of acute respiratory infection of the influenza type and laboratory confirmation of influenza A/H1N1.
[h=4]RESULTS:[/h] 64 patients were included, mostly male, median age of 48.3 months. Chronic underlying diseases were found in 73% of the patients, and these patients evolved to the most unfavorable outcome. About vaccination, of the 57 patients with an age range for vaccination, only 28% had complete vaccination coverage. The main clinical manifestations found in the included patients were fever, cough, intercostal indrawing, wheezing, tachypnea and pulmonary crackles. These patients were mainly followed-up with laboratory tests and chest X-ray. Consolidation was evident in 43% of patients followed by interstitial infiltrate in 33%. A five-day course of neuraminidase inhibitor was prescribed for all patients, as recommended by the WHO, but due to the complications, 73% of the patients required antibiotic therapy, and 61% oxygen therapy. The majority of patients had a favorable outcome, but 11 required intensive care and one died.
[h=4]CONCLUSIONS:[/h] A/H1N1 influenza persists as an important public health problem, mainly due to high morbidity and hospitalization rates. It is important to identify patients with A/H1N1 influenza and clinical situations with higher risk of complications. Through this study, it is possible to analyze the characteristics of pediatric patients with A/H1N1 influenza and mainly to emphasize assistance of populations with comorbidities, since they present higher rates of complications and death.
Copyright ? 2018 Sociedade Brasileira de Infectologia. Published by Elsevier Editora Ltda. All rights reserved.
PMID: 29879425 DOI: 10.1016/j.bjid.2018.05.004
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[h=1]Impact of A/H1N1 influenza in children at a Brazilian University Hospital.[/h] Biondo GF[SUP]1[/SUP], Santana JC[SUP]2[/SUP], Lago PM[SUP]2[/SUP], Piva J[SUP]2[/SUP], Souza PRA[SUP]3[/SUP], Gaulke JG[SUP]3[/SUP], Sebben JM[SUP]4[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] A/H1N1 influenza is a viral disease that affects a significant part of the population mainly in winter, leading to increased number of medical consultations, hospitalizations and consequently care spending in emergency.
[h=4]METHODS:[/h] This is a case-series retrospective study, involving patients admitted to a tertiary hospital in southern Brazil in 2016 with a clinical diagnosis of acute respiratory infection of the influenza type and laboratory confirmation of influenza A/H1N1.
[h=4]RESULTS:[/h] 64 patients were included, mostly male, median age of 48.3 months. Chronic underlying diseases were found in 73% of the patients, and these patients evolved to the most unfavorable outcome. About vaccination, of the 57 patients with an age range for vaccination, only 28% had complete vaccination coverage. The main clinical manifestations found in the included patients were fever, cough, intercostal indrawing, wheezing, tachypnea and pulmonary crackles. These patients were mainly followed-up with laboratory tests and chest X-ray. Consolidation was evident in 43% of patients followed by interstitial infiltrate in 33%. A five-day course of neuraminidase inhibitor was prescribed for all patients, as recommended by the WHO, but due to the complications, 73% of the patients required antibiotic therapy, and 61% oxygen therapy. The majority of patients had a favorable outcome, but 11 required intensive care and one died.
[h=4]CONCLUSIONS:[/h] A/H1N1 influenza persists as an important public health problem, mainly due to high morbidity and hospitalization rates. It is important to identify patients with A/H1N1 influenza and clinical situations with higher risk of complications. Through this study, it is possible to analyze the characteristics of pediatric patients with A/H1N1 influenza and mainly to emphasize assistance of populations with comorbidities, since they present higher rates of complications and death.
Copyright ? 2018 Sociedade Brasileira de Infectologia. Published by Elsevier Editora Ltda. All rights reserved.
PMID: 29879425 DOI: 10.1016/j.bjid.2018.05.004
Free full text