tetano
Editor, Senior Moderator
Immunotherapy
. 2022 Feb 21.
doi: 10.2217/imt-2021-0168. Online ahead of print.
A global picture: therapeutic perspectives for COVID-19
Vivek P Chavda[SUP] 1 2 [/SUP], Carron Kapadia[SUP] 1 [/SUP], Shailvi Soni[SUP] 1 [/SUP], Riddhi Prajapati[SUP] 1 [/SUP], Subhash C Chauhan[SUP] 3 4 [/SUP], Murali M Yallapu[SUP] 3 4 [/SUP], Vasso Apostolopoulos[SUP] 5 [/SUP]
Affiliations
Abstract
The COVID-19 pandemic is a lethal virus outbreak by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), which has severely affected human lives and the global economy. The most vital part of the research and development of therapeutic agents is to design drug products to manage COVID-19 efficiently. Numerous attempts have been in place to determine the optimal drug dose and combination of drugs to treat the disease on a global scale. This article documents the information available on SARS-CoV-2 and its life cycle, which will aid in the development of the potential treatment options. A consolidated summary of several natural and repurposed drugs to manage COVID-19 is depicted with summary of current vaccine development. People with high age, comorbity and concomitant illnesses such as overweight, metabolic disorders, pulmonary disease, coronary heart disease, renal failure, fatty liver and neoplastic disorders are more prone to create serious COVID-19 and its consequences. This article also presents an overview of post-COVID-19 complications in patients.
Keywords: COVID-19; SARS-CoV-2; coronavirus; drug discovery process; drug repurposing; drug target; pandemic; vaccines.
. 2022 Feb 21.
doi: 10.2217/imt-2021-0168. Online ahead of print.
A global picture: therapeutic perspectives for COVID-19
Vivek P Chavda[SUP] 1 2 [/SUP], Carron Kapadia[SUP] 1 [/SUP], Shailvi Soni[SUP] 1 [/SUP], Riddhi Prajapati[SUP] 1 [/SUP], Subhash C Chauhan[SUP] 3 4 [/SUP], Murali M Yallapu[SUP] 3 4 [/SUP], Vasso Apostolopoulos[SUP] 5 [/SUP]
Affiliations
- PMID: 35187954
- DOI: 10.2217/imt-2021-0168
Abstract
The COVID-19 pandemic is a lethal virus outbreak by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), which has severely affected human lives and the global economy. The most vital part of the research and development of therapeutic agents is to design drug products to manage COVID-19 efficiently. Numerous attempts have been in place to determine the optimal drug dose and combination of drugs to treat the disease on a global scale. This article documents the information available on SARS-CoV-2 and its life cycle, which will aid in the development of the potential treatment options. A consolidated summary of several natural and repurposed drugs to manage COVID-19 is depicted with summary of current vaccine development. People with high age, comorbity and concomitant illnesses such as overweight, metabolic disorders, pulmonary disease, coronary heart disease, renal failure, fatty liver and neoplastic disorders are more prone to create serious COVID-19 and its consequences. This article also presents an overview of post-COVID-19 complications in patients.
Keywords: COVID-19; SARS-CoV-2; coronavirus; drug discovery process; drug repurposing; drug target; pandemic; vaccines.