Ganseerpel
Advisory Board, Senior Moderator
A new systematic approach to the subject we discussed here.
PNAS | January 2, 2007 | vol. 104 | no. 1 | 246-251
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[FONT=verdana,arial,helvetica,sans-serif][SIZE=-1] Previous Article[/SIZE][/FONT] | [FONT=verdana,arial,helvetica,sans-serif][SIZE=-1]Table of Contents[/SIZE][/FONT] | [FONT=verdana,arial,helvetica,sans-serif][SIZE=-1]Next Article[/SIZE][/FONT] 
[SIZE=-2]BIOLOGICAL SCIENCES / IMMUNOLOGY[/SIZE]
[SIZE=+2]Ab and T cell epitopes of influenza A virus, knowledge and opportunities [/SIZE]
</NOBR><NOBR>Huynh-Hoa Bui<SUP>*</SUP></NOBR>, <NOBR>Bjoern Peters<SUP>*</SUP></NOBR>, <NOBR>Erika Assarsson<SUP>*</SUP></NOBR>, <NOBR>Innocent Mbawuike<SUP>
</SUP></NOBR>, and <NOBR>Alessandro Sette<SUP>*</SUP><SUP>,
</SUP></NOBR>
*Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037; and <SUP>
</SUP>Department of Molecular Virology, Baylor College of Medicine, Houston, TX 77030
Communicated by Howard M. Grey, La Jolla Institute for Allergy and Immunology, San Diego, CA, November 1, 2006 (received for review October 1, 2006)
<!-- ABS -->The Immune Epitope Database and Analysis Resources (IEDB) <SUP> </SUP>was recently developed to capture epitope related data. IEDB<SUP> </SUP>also hosts various bioinformatics tools that can be used to<SUP> </SUP>identify novel epitopes as well as to analyze and visualize<SUP> </SUP>existing epitope data. Herein, a comprehensive analysis was<SUP> </SUP>undertaken (i) to compile and inventory existing knowledge regarding<SUP> </SUP>influenza A epitopes and (ii) to determine possible cross-reactivities<SUP> </SUP>of identified epitopes among avian H5N1 and human influenza<SUP> </SUP>strains. At present, IEDB contains >600 different epitopes<SUP> </SUP>derived from 58 different strains and 10 influenza A proteins.<SUP> </SUP>By using the IEDB analysis resources, conservancy analyses were<SUP> </SUP>performed, and several conserved and possibly cross-reactive<SUP> </SUP>epitopes were identified. Significant gaps in the current knowledge<SUP> </SUP>were also revealed, including paucity of Ab epitopes in comparison<SUP> </SUP>with T cell epitopes, limited number of epitopes reported for<SUP> </SUP>avian influenza strains/subtypes, and limited number of epitopes<SUP> </SUP>reported from proteins other than hemagglutinin and nucleoprotein.<SUP> </SUP>This analysis provides a resource for researchers to access<SUP> </SUP>existing influenza epitope data. At the same time, the analysis<SUP> </SUP>illustrates gaps in our collective knowledge that should inspire<SUP> </SUP>directions for further study of immunity against the influenza<SUP> </SUP>A virus.<SUP> </SUP>
[SIZE=-1]B lymphocytes | T lymphocytes | conservancy | pandemic cross-reactivity[/SIZE]
PNAS | January 2, 2007 | vol. 104 | no. 1 | 246-251
<TABLE class=content_box_outer_table align=right><TBODY><TR><TD><!-- beginning of inner table --><TABLE class=content_box_inner_table width=275><!-- citation --><TBODY><TR><TD class=content_box_title_highlight colSpan=2>This Article</TD></TR><TR><TD class=content_box_space_between_sections colSpan=2>
[FONT=verdana,arial,helvetica,sans-serif][SIZE=-1] Previous Article[/SIZE][/FONT] | [FONT=verdana,arial,helvetica,sans-serif][SIZE=-1]Table of Contents[/SIZE][/FONT] | [FONT=verdana,arial,helvetica,sans-serif][SIZE=-1]Next Article[/SIZE][/FONT] [SIZE=-2]BIOLOGICAL SCIENCES / IMMUNOLOGY[/SIZE]
[SIZE=+2]Ab and T cell epitopes of influenza A virus, knowledge and opportunities [/SIZE]
</NOBR><NOBR>Huynh-Hoa Bui<SUP>*</SUP></NOBR>, <NOBR>Bjoern Peters<SUP>*</SUP></NOBR>, <NOBR>Erika Assarsson<SUP>*</SUP></NOBR>, <NOBR>Innocent Mbawuike<SUP>
*Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037; and <SUP>
Communicated by Howard M. Grey, La Jolla Institute for Allergy and Immunology, San Diego, CA, November 1, 2006 (received for review October 1, 2006)
<!-- ABS -->The Immune Epitope Database and Analysis Resources (IEDB) <SUP> </SUP>was recently developed to capture epitope related data. IEDB<SUP> </SUP>also hosts various bioinformatics tools that can be used to<SUP> </SUP>identify novel epitopes as well as to analyze and visualize<SUP> </SUP>existing epitope data. Herein, a comprehensive analysis was<SUP> </SUP>undertaken (i) to compile and inventory existing knowledge regarding<SUP> </SUP>influenza A epitopes and (ii) to determine possible cross-reactivities<SUP> </SUP>of identified epitopes among avian H5N1 and human influenza<SUP> </SUP>strains. At present, IEDB contains >600 different epitopes<SUP> </SUP>derived from 58 different strains and 10 influenza A proteins.<SUP> </SUP>By using the IEDB analysis resources, conservancy analyses were<SUP> </SUP>performed, and several conserved and possibly cross-reactive<SUP> </SUP>epitopes were identified. Significant gaps in the current knowledge<SUP> </SUP>were also revealed, including paucity of Ab epitopes in comparison<SUP> </SUP>with T cell epitopes, limited number of epitopes reported for<SUP> </SUP>avian influenza strains/subtypes, and limited number of epitopes<SUP> </SUP>reported from proteins other than hemagglutinin and nucleoprotein.<SUP> </SUP>This analysis provides a resource for researchers to access<SUP> </SUP>existing influenza epitope data. At the same time, the analysis<SUP> </SUP>illustrates gaps in our collective knowledge that should inspire<SUP> </SUP>directions for further study of immunity against the influenza<SUP> </SUP>A virus.<SUP> </SUP>
[SIZE=-1]B lymphocytes | T lymphocytes | conservancy | pandemic cross-reactivity[/SIZE]
