tetano
Editor, Senior Moderator
Immunology
. 2024 Aug 19.
doi: 10.1111/imm.13844. Online ahead of print. Advancement in the development of mRNA-based vaccines for respiratory viruses
Tays Troncoso-Bravo[SUP] 1 2 [/SUP], Mario A Ramírez[SUP] 1 [/SUP], Ricardo A Loaiza[SUP] 1 [/SUP], Carolina Román-Cárdenas[SUP] 1 [/SUP], Georgios Papazisis[SUP] 3 4 [/SUP], Daniel Garrido[SUP] 2 [/SUP], Pablo A González[SUP] 1 [/SUP], Susan M Bueno[SUP] 1 [/SUP], Alexis M Kalergis[SUP] 1 5 [/SUP]
Affiliations
Acute respiratory infections are the leading cause of death and illness in children under 5 years old and represent a significant burden in older adults. Primarily caused by viruses infecting the lower respiratory tract, symptoms include cough, congestion, and low-grade fever, potentially leading to bronchiolitis and pneumonia. Messenger ribonucleic acid (mRNA)-based vaccines are biopharmaceutical formulations that employ mRNA molecules to induce specific immune responses, facilitating the expression of viral or bacterial antigens and promoting immunization against infectious diseases. Notably, this technology had significant relevance during the COVID-19 pandemic, as these formulations helped to limit SARS-CoV-2 virus infections, hospitalizations, and deaths. Importantly, mRNA vaccines promise to be implemented as new alternatives for fighting other respiratory viruses, such as influenza, human respiratory syncytial virus, and human metapneumovirus. This review article analyzes mRNA-based vaccines' main contributions, perspectives, challenges, and implications against respiratory viruses.
Keywords: mRNA; respiratory diseases; vaccine; viral infection.
. 2024 Aug 19.
doi: 10.1111/imm.13844. Online ahead of print. Advancement in the development of mRNA-based vaccines for respiratory viruses
Tays Troncoso-Bravo[SUP] 1 2 [/SUP], Mario A Ramírez[SUP] 1 [/SUP], Ricardo A Loaiza[SUP] 1 [/SUP], Carolina Román-Cárdenas[SUP] 1 [/SUP], Georgios Papazisis[SUP] 3 4 [/SUP], Daniel Garrido[SUP] 2 [/SUP], Pablo A González[SUP] 1 [/SUP], Susan M Bueno[SUP] 1 [/SUP], Alexis M Kalergis[SUP] 1 5 [/SUP]
Affiliations
- PMID: 39161170
- DOI: 10.1111/imm.13844
Acute respiratory infections are the leading cause of death and illness in children under 5 years old and represent a significant burden in older adults. Primarily caused by viruses infecting the lower respiratory tract, symptoms include cough, congestion, and low-grade fever, potentially leading to bronchiolitis and pneumonia. Messenger ribonucleic acid (mRNA)-based vaccines are biopharmaceutical formulations that employ mRNA molecules to induce specific immune responses, facilitating the expression of viral or bacterial antigens and promoting immunization against infectious diseases. Notably, this technology had significant relevance during the COVID-19 pandemic, as these formulations helped to limit SARS-CoV-2 virus infections, hospitalizations, and deaths. Importantly, mRNA vaccines promise to be implemented as new alternatives for fighting other respiratory viruses, such as influenza, human respiratory syncytial virus, and human metapneumovirus. This review article analyzes mRNA-based vaccines' main contributions, perspectives, challenges, and implications against respiratory viruses.
Keywords: mRNA; respiratory diseases; vaccine; viral infection.