tetano
Editor, Senior Moderator
Immunol Rev
. 2022 Jun 22.
doi: 10.1111/imr.13089. Online ahead of print.
Immunological memory to SARS-CoV-2 infection and COVID-19 vaccines
Alessandro Sette[SUP] 1 2 [/SUP], Shane Crotty[SUP] 1 2 [/SUP]
Affiliations
Abstract
Immunological memory is the basis of protective immunity provided by vaccines and previous infections. Immunological memory can develop from multiple branches of the adaptive immune system, including CD4 T cells, CD8 T cells, B cells, and long-lasting antibody responses. Extraordinary progress has been made in understanding memory to SARS-CoV-2 infection and COVID-19 vaccines, addressing development; quantitative and qualitative features of different cellular and anatomical compartments; and durability of each cellular component and antibodies. Given the sophistication of the measurements; the size of the human studies; the use of longitudinal samples and cross-sectional studies; and head-to-head comparisons between infection and vaccines or between multiple vaccines, the understanding of immune memory for 1 year to SARS-CoV-2 infection and vaccines already supersedes that of any other acute infectious disease. This knowledge may help inform public policies regarding COVID-19 and COVID-19 vaccines, as well as the scientific development of future vaccines against SARS-CoV-2 and other diseases.
Keywords: adenoviral vectors; coronavirus; hybrid immunity; mRNA vaccines; memory B cells; memory T cells; natural immunity; protein vaccine.
. 2022 Jun 22.
doi: 10.1111/imr.13089. Online ahead of print.
Immunological memory to SARS-CoV-2 infection and COVID-19 vaccines
Alessandro Sette[SUP] 1 2 [/SUP], Shane Crotty[SUP] 1 2 [/SUP]
Affiliations
- PMID: 35733376
- DOI: 10.1111/imr.13089
Abstract
Immunological memory is the basis of protective immunity provided by vaccines and previous infections. Immunological memory can develop from multiple branches of the adaptive immune system, including CD4 T cells, CD8 T cells, B cells, and long-lasting antibody responses. Extraordinary progress has been made in understanding memory to SARS-CoV-2 infection and COVID-19 vaccines, addressing development; quantitative and qualitative features of different cellular and anatomical compartments; and durability of each cellular component and antibodies. Given the sophistication of the measurements; the size of the human studies; the use of longitudinal samples and cross-sectional studies; and head-to-head comparisons between infection and vaccines or between multiple vaccines, the understanding of immune memory for 1 year to SARS-CoV-2 infection and vaccines already supersedes that of any other acute infectious disease. This knowledge may help inform public policies regarding COVID-19 and COVID-19 vaccines, as well as the scientific development of future vaccines against SARS-CoV-2 and other diseases.
Keywords: adenoviral vectors; coronavirus; hybrid immunity; mRNA vaccines; memory B cells; memory T cells; natural immunity; protein vaccine.