tetano
Editor, Senior Moderator
Immunol Med
. 2022 May 27;1-6.
doi: 10.1080/25785826.2022.2079369. Online ahead of print.
Signaling via dopamine and adenosine receptors modulate viral peptide-specific and T-cell IL-8 response in COVID-19
Mieko Tokano[SUP] 1 2 [/SUP], Rie Takagi[SUP] 1 [/SUP], Masaaki Kawano[SUP] 1 [/SUP], Shigefumi Maesaki[SUP] 2 [/SUP], Norihito Tarumoto[SUP] 2 [/SUP], Sho Matsushita[SUP] 1 3 [/SUP]
Affiliations
Abstract
B-cell but not T-cell responses have been extensively studied using peripheral blood mononuclear cells (PBMCs) obtained from patients with coronavirus disease 2019 (COVID-19). Our recent study showed that not only T-helper (Th) 17 but also Th1 cells directly produce interleukin (IL)-8, a major source of neutrophilic inflammation, which is also known to induce disseminated intravascular coagulation (DIC) in COVID-19 patients. Neutrophilic inflammation caused by IL-17A or IL-8 can be fatal; thus, therapeutic intervention is highly expected. The present study aimed to investigate the T-cell responses in the Japanese patients. We synthesized spike protein-derived 15-mer peptides that are expected to bind to HLA class II allelic products frequently observed in the Japanese population, and checked the T-cell responses in Japanese patients with COVID-19. We have found that (i) patients show marked IL-8 but not IL-17A responses; (ii) these responses are restricted by HLA-DR; and (iii) IL-8 responses are abrogated by a dopamine D2 like receptor (D2R) agonist, ropinirole, and an adenosine A2a receptor (A2aR) antagonist, istradefylline. Compounds used for the treatment of Parkinson's disease may ease DIC in COVID-19. (183 words).
Keywords: Adenosine receptors; CD4+ T cells; COVID-19; IL-8; dopamine receptors.
. 2022 May 27;1-6.
doi: 10.1080/25785826.2022.2079369. Online ahead of print.
Signaling via dopamine and adenosine receptors modulate viral peptide-specific and T-cell IL-8 response in COVID-19
Mieko Tokano[SUP] 1 2 [/SUP], Rie Takagi[SUP] 1 [/SUP], Masaaki Kawano[SUP] 1 [/SUP], Shigefumi Maesaki[SUP] 2 [/SUP], Norihito Tarumoto[SUP] 2 [/SUP], Sho Matsushita[SUP] 1 3 [/SUP]
Affiliations
- PMID: 35623041
- DOI: 10.1080/25785826.2022.2079369
Abstract
B-cell but not T-cell responses have been extensively studied using peripheral blood mononuclear cells (PBMCs) obtained from patients with coronavirus disease 2019 (COVID-19). Our recent study showed that not only T-helper (Th) 17 but also Th1 cells directly produce interleukin (IL)-8, a major source of neutrophilic inflammation, which is also known to induce disseminated intravascular coagulation (DIC) in COVID-19 patients. Neutrophilic inflammation caused by IL-17A or IL-8 can be fatal; thus, therapeutic intervention is highly expected. The present study aimed to investigate the T-cell responses in the Japanese patients. We synthesized spike protein-derived 15-mer peptides that are expected to bind to HLA class II allelic products frequently observed in the Japanese population, and checked the T-cell responses in Japanese patients with COVID-19. We have found that (i) patients show marked IL-8 but not IL-17A responses; (ii) these responses are restricted by HLA-DR; and (iii) IL-8 responses are abrogated by a dopamine D2 like receptor (D2R) agonist, ropinirole, and an adenosine A2a receptor (A2aR) antagonist, istradefylline. Compounds used for the treatment of Parkinson's disease may ease DIC in COVID-19. (183 words).
Keywords: Adenosine receptors; CD4+ T cells; COVID-19; IL-8; dopamine receptors.