tetano
Editor, Senior Moderator
Microbiol Immunol. 2013 Aug 1. doi: 10.1111/1348-0421.12086. [Epub ahead of print]
Immunogenicity of inactivated seasonal influenza vaccine in adult and pediatric liver transplant recipients over two seasons.
Suzuki M, Torii Y, Kawada JI, Kimura H, Kamei H, Onishi Y, Kaneko K, Ando H, Kiuchi T, Ito Y.
Source
Department of Pediatrics, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan.
Abstract
Immunological responses to influenza vaccination to patients after liver transplantation are not fully elucidated. To compare immunogenicity between adult and pediatric recipients, 16 adult and 15 pediatric living donor liver transplantation recipients in the 2010-11 influenza season, and 53 adult and 21 pediatric recipients in the 2011-12 season with inactivated influenza vaccines were investigated. Seroprotection rates (hemagglutinin-inhibition [HI] antibody titer 1:40) were 50-94% to all three antigens among adults and 27-80% among children through the two seasons. Seroconversion rates (4-fold or more HI antibody rise) were 32-56% among adults and 13-67% among children through the two seasons. No significant differences were observed between the two groups. Next, 20 of 53 adult and 13 of 21 pediatric recipients received a vaccine including identical antigens over the two seasons. Geometric mean titer fold increases of all three antigens in adult recipients were significantly lower compared with recipients without the preceding vaccination. In contrast, in pediatric recipients, no remarkable differences were found between the group with and without the preceding vaccination. The number of patients with rejection did not differ significantly between the two groups (0/53 vs. 1/21) in the 2011-12 season. The incidence of influenza after vaccination was significantly different between adult and pediatric recipients, respectively (0/16 vs. 5/15 in 2010-11, 0/53 vs. 3/21 in 2011-12). Overall, there were no significant differences in antibody responses between adult and pediatric groups. Influenza infection was more frequent in pediatric recipients. Long-term response to the preceding vaccination appeared to be insufficient in both groups.
This article is protected by copyright. All rights reserved.
KEYWORDS:
immunogenicity, influenza vaccination, liver transplantation
PMID:
23909408
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23909408
Immunogenicity of inactivated seasonal influenza vaccine in adult and pediatric liver transplant recipients over two seasons.
Suzuki M, Torii Y, Kawada JI, Kimura H, Kamei H, Onishi Y, Kaneko K, Ando H, Kiuchi T, Ito Y.
Source
Department of Pediatrics, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan.
Abstract
Immunological responses to influenza vaccination to patients after liver transplantation are not fully elucidated. To compare immunogenicity between adult and pediatric recipients, 16 adult and 15 pediatric living donor liver transplantation recipients in the 2010-11 influenza season, and 53 adult and 21 pediatric recipients in the 2011-12 season with inactivated influenza vaccines were investigated. Seroprotection rates (hemagglutinin-inhibition [HI] antibody titer 1:40) were 50-94% to all three antigens among adults and 27-80% among children through the two seasons. Seroconversion rates (4-fold or more HI antibody rise) were 32-56% among adults and 13-67% among children through the two seasons. No significant differences were observed between the two groups. Next, 20 of 53 adult and 13 of 21 pediatric recipients received a vaccine including identical antigens over the two seasons. Geometric mean titer fold increases of all three antigens in adult recipients were significantly lower compared with recipients without the preceding vaccination. In contrast, in pediatric recipients, no remarkable differences were found between the group with and without the preceding vaccination. The number of patients with rejection did not differ significantly between the two groups (0/53 vs. 1/21) in the 2011-12 season. The incidence of influenza after vaccination was significantly different between adult and pediatric recipients, respectively (0/16 vs. 5/15 in 2010-11, 0/53 vs. 3/21 in 2011-12). Overall, there were no significant differences in antibody responses between adult and pediatric groups. Influenza infection was more frequent in pediatric recipients. Long-term response to the preceding vaccination appeared to be insufficient in both groups.
This article is protected by copyright. All rights reserved.
KEYWORDS:
immunogenicity, influenza vaccination, liver transplantation
PMID:
23909408
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23909408