tetano
Editor, Senior Moderator
Clin Vaccine Immunol. 2011 Jul 27. [Epub ahead of print]
Immunogenicity, boostability and sustainability of the immune response after vaccination against influenza A (H1N1) 2009 in a healthy population.
Huijskens E, Rossen J, Mulder P, van Beek R, van Vugt H, Verbakel J, Rimmelzwaan G, Koopmans M, Peeters M.
Source
Laboratory of Medical Microbiology and Immunology, St. Elisabeth Hospital, Tilburg, The Netherlands.
Abstract
The emergence of a new influenza A virus (H1N1) variant in 2009 led to a world-wide vaccination program which was prepared in a relatively short period of time. This study investigated the humoral immunity against this virus before and after vaccination with a 2009 Influenza A (H1N1) Monovalent MF59-Adjuvanted Vaccine, as well as the persistence of vaccine-induced antibodies. Our prospective longitudinal study included 498 healthcare workers (mean age 43; median age 44 years). Most (89%) had never or only occasionally received a seasonal vaccine, and 11% were annually vaccinated (on average > 10 years). Antibody-titers were determined by a hemagglutination-inhibition (HI) assay at baseline, 3 weeks after the first vaccination and 5 weeks and 7 months after the second vaccination. Four hundred and thirty-five persons received two doses of the 2009 vaccine. After the first dose, 79.5% developed a HI-titer ≥ 40. This percentage increased to 83.3% after the second dose. Persistent antibodies were found in 71.9% of the no annual vaccination group and in 43.8% of the annual vaccination group. The latter group tended to have lower HI-titers (p = 0.09). With increasing age, HI titers decreased significantly by 2.4% per year. A single dose of the 2009 vaccine was immunogenic in almost 80% of the study population, whereas an additional dose only resulted in significantly increased titers in persons over 50. Finally, a reduced HI antibody response against the 2009 vaccine was found in adults who had previously received seasonal influenza vaccination. More studies on the effect of yearly seasonal influenza vaccination on the immune response are warranted.
PMID:
21795459
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/21795459
Immunogenicity, boostability and sustainability of the immune response after vaccination against influenza A (H1N1) 2009 in a healthy population.
Huijskens E, Rossen J, Mulder P, van Beek R, van Vugt H, Verbakel J, Rimmelzwaan G, Koopmans M, Peeters M.
Source
Laboratory of Medical Microbiology and Immunology, St. Elisabeth Hospital, Tilburg, The Netherlands.
Abstract
The emergence of a new influenza A virus (H1N1) variant in 2009 led to a world-wide vaccination program which was prepared in a relatively short period of time. This study investigated the humoral immunity against this virus before and after vaccination with a 2009 Influenza A (H1N1) Monovalent MF59-Adjuvanted Vaccine, as well as the persistence of vaccine-induced antibodies. Our prospective longitudinal study included 498 healthcare workers (mean age 43; median age 44 years). Most (89%) had never or only occasionally received a seasonal vaccine, and 11% were annually vaccinated (on average > 10 years). Antibody-titers were determined by a hemagglutination-inhibition (HI) assay at baseline, 3 weeks after the first vaccination and 5 weeks and 7 months after the second vaccination. Four hundred and thirty-five persons received two doses of the 2009 vaccine. After the first dose, 79.5% developed a HI-titer ≥ 40. This percentage increased to 83.3% after the second dose. Persistent antibodies were found in 71.9% of the no annual vaccination group and in 43.8% of the annual vaccination group. The latter group tended to have lower HI-titers (p = 0.09). With increasing age, HI titers decreased significantly by 2.4% per year. A single dose of the 2009 vaccine was immunogenic in almost 80% of the study population, whereas an additional dose only resulted in significantly increased titers in persons over 50. Finally, a reduced HI antibody response against the 2009 vaccine was found in adults who had previously received seasonal influenza vaccination. More studies on the effect of yearly seasonal influenza vaccination on the immune response are warranted.
PMID:
21795459
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/21795459