Giuseppe
Emeritus
Differential effects of age, cytomegalovirus-seropositivity and end-stage renal disease (ESRD) on circulating T lymphocyte subsets (Immunity and Ageing, abstract, edited)
[Source: Immunity and Ageing, full text: <cite cite="http://www.immunityageing.com/content/8/1/2">Abstract | Differential effects of age, cytomegalovirus-seropositivity and end-stage renal disease (ESRD) on circulating T lymphocyte subsets</cite>. Abstract, edited.]
Differential effects of age, cytomegalovirus-seropositivity and end-stage renal disease (ESRD) on circulating T lymphocyte subsets
Nicolle HR Litjens, Elly A de Wit and Michiel GH Betjes
Immunity & Ageing 2011, 8:2
doi:10.1186/1742-4933-8-2
Published: 8 January 2011
Abstract (provisional)
The age- and cytomegalovirus (CMV)-seropositivity-related changes in subsets and differentiation of circulating T cells were investigated in end-stage renal disease (ESRD) patients (n=139) and age-matched healthy individuals. The results show that CMV-seropositivity is associated with expansion of both CD4+ and CD8+ memory T cells which is already observed in young healthy individuals. In addition, CMV-seropositive healthy individuals have a more differentiated memory T cell profile. Only CMV-seropositive healthy individuals showed an age-dependent decrease in CD4+ naive T cells. The age-related decrease in the number of CD8+ naive T cells was CMV-independent. In contrast, all ESRD patients showed a profound naive T-cell lymphopenia at every decade. CMV-seropositivity aggravated the contraction of CD4+ naive T cells and increased the number of differentiated CD4+ and CD8+ memory T cells. In conclusion, CMV-seropositivity markedly alters the homeostasis of circulating T cells in healthy individuals and aggravates the T cell dysregulation observed in ESRD patients.
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[Source: Immunity and Ageing, full text: <cite cite="http://www.immunityageing.com/content/8/1/2">Abstract | Differential effects of age, cytomegalovirus-seropositivity and end-stage renal disease (ESRD) on circulating T lymphocyte subsets</cite>. Abstract, edited.]
Differential effects of age, cytomegalovirus-seropositivity and end-stage renal disease (ESRD) on circulating T lymphocyte subsets
Nicolle HR Litjens, Elly A de Wit and Michiel GH Betjes
Immunity & Ageing 2011, 8:2
doi:10.1186/1742-4933-8-2
Published: 8 January 2011
Abstract (provisional)
The age- and cytomegalovirus (CMV)-seropositivity-related changes in subsets and differentiation of circulating T cells were investigated in end-stage renal disease (ESRD) patients (n=139) and age-matched healthy individuals. The results show that CMV-seropositivity is associated with expansion of both CD4+ and CD8+ memory T cells which is already observed in young healthy individuals. In addition, CMV-seropositive healthy individuals have a more differentiated memory T cell profile. Only CMV-seropositive healthy individuals showed an age-dependent decrease in CD4+ naive T cells. The age-related decrease in the number of CD8+ naive T cells was CMV-independent. In contrast, all ESRD patients showed a profound naive T-cell lymphopenia at every decade. CMV-seropositivity aggravated the contraction of CD4+ naive T cells and increased the number of differentiated CD4+ and CD8+ memory T cells. In conclusion, CMV-seropositivity markedly alters the homeostasis of circulating T cells in healthy individuals and aggravates the T cell dysregulation observed in ESRD patients.
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