tetano
Editor, Senior Moderator
Clin Infect Dis. 2017 Oct 21. doi: 10.1093/cid/cix900. [Epub ahead of print]
[h=1]Immune responses to twice-annual influenza vaccination in older adults in Hong Kong.[/h] Tam YH[SUP]1[/SUP], Valkenburg SA[SUP]2[/SUP], Perera RAPM[SUP]1,[/SUP][SUP]3[/SUP], Wong JHF[SUP]1[/SUP], Fang VJ[SUP]1[/SUP], Ng TWY[SUP]1[/SUP], Kwong ASK[SUP]4[/SUP], Tsui WWS[SUP]4[/SUP], Ip DKM[SUP]1[/SUP], Poon LLM[SUP]1,[/SUP][SUP]3[/SUP], Chau CKV[SUP]4[/SUP], Barr IG[SUP]5,[/SUP][SUP]6[/SUP], Peiris JSM[SUP]1,[/SUP][SUP]3[/SUP], Cowling BJ[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]Background:[/h] Many health authorities recommend influenza vaccination of older adults to reduce disease burden. We hypothesized that in tropical and subtropical areas with more prolonged influenza seasons, twice-annual influenza vaccination might provide older adults with improved immunity against influenza.
[h=4]Methods:[/h] In 2014/15, Hong Kong experienced a substantial A(H3N2) winter epidemic with a mismatched vaccine. Local authorities procured and administered to older adults the 2015 southern hemisphere influenza vaccine which included an updated and matching A/Switzerland/9715293/2013(H3N2) strain. We compared immune parameters in pre- and post-vaccination sera from older adults ≥75 years of age who received one versus two influenza vaccines per year.
[h=4]Results:[/h] We enrolled 978 older adults with 470 vaccinations for summer 2015 and 827 vaccinations for winter 2015/16. Recipients of southern hemisphere vaccination had higher geometric mean titers (GMTs) by the hemagglutination inhibition assay against all three vaccine strains. When receiving influenza vaccination for the subsequent winter, the southern hemisphere vaccine recipients had higher pre-vaccination GMTs but lower post-vaccination GMTs, compared to those who had not received the southern hemisphere vaccine. Furthermore, cellular immunity was impacted by bi-annual vaccination, with reduced influenza-specific CD4 T cell responses in the second season of vaccination.
[h=4]Conclusions:[/h] We observed some reductions in immune responses in the twice-annual vaccination group compared to once-annual vaccination group, in the context of unchanging vaccine strains, while protection was likely to have been improved during the summer and autumn for the twice-annual vaccination group due to the continued circulation of the A/Switzerland/9715293/2013(H3N2) virus.
PMID: 29069368 DOI: 10.1093/cid/cix900
[h=1]Immune responses to twice-annual influenza vaccination in older adults in Hong Kong.[/h] Tam YH[SUP]1[/SUP], Valkenburg SA[SUP]2[/SUP], Perera RAPM[SUP]1,[/SUP][SUP]3[/SUP], Wong JHF[SUP]1[/SUP], Fang VJ[SUP]1[/SUP], Ng TWY[SUP]1[/SUP], Kwong ASK[SUP]4[/SUP], Tsui WWS[SUP]4[/SUP], Ip DKM[SUP]1[/SUP], Poon LLM[SUP]1,[/SUP][SUP]3[/SUP], Chau CKV[SUP]4[/SUP], Barr IG[SUP]5,[/SUP][SUP]6[/SUP], Peiris JSM[SUP]1,[/SUP][SUP]3[/SUP], Cowling BJ[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]Background:[/h] Many health authorities recommend influenza vaccination of older adults to reduce disease burden. We hypothesized that in tropical and subtropical areas with more prolonged influenza seasons, twice-annual influenza vaccination might provide older adults with improved immunity against influenza.
[h=4]Methods:[/h] In 2014/15, Hong Kong experienced a substantial A(H3N2) winter epidemic with a mismatched vaccine. Local authorities procured and administered to older adults the 2015 southern hemisphere influenza vaccine which included an updated and matching A/Switzerland/9715293/2013(H3N2) strain. We compared immune parameters in pre- and post-vaccination sera from older adults ≥75 years of age who received one versus two influenza vaccines per year.
[h=4]Results:[/h] We enrolled 978 older adults with 470 vaccinations for summer 2015 and 827 vaccinations for winter 2015/16. Recipients of southern hemisphere vaccination had higher geometric mean titers (GMTs) by the hemagglutination inhibition assay against all three vaccine strains. When receiving influenza vaccination for the subsequent winter, the southern hemisphere vaccine recipients had higher pre-vaccination GMTs but lower post-vaccination GMTs, compared to those who had not received the southern hemisphere vaccine. Furthermore, cellular immunity was impacted by bi-annual vaccination, with reduced influenza-specific CD4 T cell responses in the second season of vaccination.
[h=4]Conclusions:[/h] We observed some reductions in immune responses in the twice-annual vaccination group compared to once-annual vaccination group, in the context of unchanging vaccine strains, while protection was likely to have been improved during the summer and autumn for the twice-annual vaccination group due to the continued circulation of the A/Switzerland/9715293/2013(H3N2) virus.
PMID: 29069368 DOI: 10.1093/cid/cix900