tetano
Editor, Senior Moderator
Antivir Ther. 2018 Jan 26. doi: 10.3851/IMP3222. [Epub ahead of print]
[h=1]Immune response after a single intravenous peramivir administration in children with influenza.[/h] Sato M[SUP]1[/SUP], Hashimoto K[SUP]1[/SUP], Kawasaki Y[SUP]1[/SUP], Hosoya M[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] Immune response after intravenous peramivir administration, which is approved for children with influenza infection in Japan, is unclear.
[h=4]METHODS:[/h] Kinetics of viral load and serum cytokine levels before and after peramivir therapy were analysed in 17 and 8 hospitalized children infected with influenza A and B, respectively. Additionally, haemadsorption inhibition (HI) titre was measured. The first day of hospital admission was defined as day 0.
[h=4]RESULTS:[/h] Serum interleukin (IL)-6 levels in influenza A-infected children significantly decreased after peramivir administration, unlike in those with influenza B where a decrease on day 1 was followed by an increase on day 2. Serum IL-6 kinetics was similar to viral load kinetics in both influenza A- and B-infected children between days 0 and 2. Serum IL-8 levels gradually decreased after peramivir therapy in influenza A-infected children but increased between days 1 and 2 in influenza B-infected children. Conversely, serum IL-10 levels gradually decreased over time. Serum interferon-γ and granulocyte macrophage colony-stimulating factor levels remained low until day 5. Day 0-4 serum HI titres were <4-fold in all children infected with influenza A or B. Additionally, day 5 HI titres were positive in 4 of 6 influenza A cases and all 3 influenza B cases.
[h=4]CONCLUSIONS:[/h] Our results suggest that viral load and inflammatory cytokine kinetics were associated with the antiviral therapy used and that second peramivir administration should be considered in influenza B as well as highlight antiviral agents as key determinants of the clinical course of influenza virus infection in children.
PMID: 29372885 DOI: 10.3851/IMP3222
[h=1]Immune response after a single intravenous peramivir administration in children with influenza.[/h] Sato M[SUP]1[/SUP], Hashimoto K[SUP]1[/SUP], Kawasaki Y[SUP]1[/SUP], Hosoya M[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] Immune response after intravenous peramivir administration, which is approved for children with influenza infection in Japan, is unclear.
[h=4]METHODS:[/h] Kinetics of viral load and serum cytokine levels before and after peramivir therapy were analysed in 17 and 8 hospitalized children infected with influenza A and B, respectively. Additionally, haemadsorption inhibition (HI) titre was measured. The first day of hospital admission was defined as day 0.
[h=4]RESULTS:[/h] Serum interleukin (IL)-6 levels in influenza A-infected children significantly decreased after peramivir administration, unlike in those with influenza B where a decrease on day 1 was followed by an increase on day 2. Serum IL-6 kinetics was similar to viral load kinetics in both influenza A- and B-infected children between days 0 and 2. Serum IL-8 levels gradually decreased after peramivir therapy in influenza A-infected children but increased between days 1 and 2 in influenza B-infected children. Conversely, serum IL-10 levels gradually decreased over time. Serum interferon-γ and granulocyte macrophage colony-stimulating factor levels remained low until day 5. Day 0-4 serum HI titres were <4-fold in all children infected with influenza A or B. Additionally, day 5 HI titres were positive in 4 of 6 influenza A cases and all 3 influenza B cases.
[h=4]CONCLUSIONS:[/h] Our results suggest that viral load and inflammatory cytokine kinetics were associated with the antiviral therapy used and that second peramivir administration should be considered in influenza B as well as highlight antiviral agents as key determinants of the clinical course of influenza virus infection in children.
PMID: 29372885 DOI: 10.3851/IMP3222