tetano
Editor, Senior Moderator
Immune Netw
. 2023 Aug 11;23(4):e33.
doi: 10.4110/in.2023.23.e33. eCollection 2023 Aug. SARS-CoV-2 mRNA Vaccine Elicits Sustained T Cell Responses Against the Omicron Variant in Adolescents
Sujin Choi[SUP] 1 2 [/SUP], Sang-Hoon Kim[SUP] 3 [/SUP], Mi Seon Han[SUP] 2 4 [/SUP], Yoonsun Yoon[SUP] 5 [/SUP], Yun-Kyung Kim[SUP] 6 [/SUP], Hye-Kyung Cho[SUP] 7 [/SUP], Ki Wook Yun[SUP] 2 8 [/SUP], Seung Ha Song[SUP] 2 8 [/SUP], Bin Ahn[SUP] 2 8 [/SUP], Ye Kyung Kim[SUP] 2 8 [/SUP], Sung Hwan Choi[SUP] 8 [/SUP], Young June Choe[SUP] 9 [/SUP], Heeji Lim[SUP] 10 [/SUP], Eun Bee Choi[SUP] 10 [/SUP], Kwangwook Kim[SUP] 10 [/SUP], Seokhwan Hyeon[SUP] 10 [/SUP], Hye Jung Lim[SUP] 10 [/SUP], Byung-Chul Kim[SUP] 10 [/SUP], Yoo-Kyoung Lee[SUP] 10 [/SUP], Eun Hwa Choi[SUP] 2 8 [/SUP], Eui-Cheol Shin[SUP] 3 11 [/SUP], Hyunju Lee[SUP] 1 2 [/SUP]
Affiliations
Vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been acknowledged as an effective mean of preventing infection and hospitalization. However, the emergence of highly transmissible SARS-CoV-2 variants of concern (VOCs) has led to substantial increase in infections among children and adolescents. Vaccine-induced immunity and longevity have not been well defined in this population. Therefore, we aimed to analyze humoral and cellular immune responses against ancestral and SARS-CoV-2 variants after two shots of the BNT162b2 vaccine in healthy adolescents. Although vaccination induced a robust increase of spike-specific binding Abs and neutralizing Abs against the ancestral and SARS-CoV-2 variants, the neutralizing activity against the Omicron variant was significantly low. On the contrary, vaccine-induced memory CD4[SUP]+[/SUP] T cells exhibited substantial responses against both ancestral and Omicron spike proteins. Notably, CD4[SUP]+[/SUP] T cell responses against both ancestral and Omicron strains were preserved at 3 months after two shots of the BNT162b2 vaccine without waning. Polyfunctionality of vaccine-induced memory T cells was also preserved in response to Omicron spike protein. The present findings characterize the protective immunity of vaccination for adolescents in the era of continuous emergence of variants/subvariants.
Keywords: Adolescent; COVID-19 vaccines; SARS-CoV-2; SARS-CoV-2 variants.
. 2023 Aug 11;23(4):e33.
doi: 10.4110/in.2023.23.e33. eCollection 2023 Aug. SARS-CoV-2 mRNA Vaccine Elicits Sustained T Cell Responses Against the Omicron Variant in Adolescents
Sujin Choi[SUP] 1 2 [/SUP], Sang-Hoon Kim[SUP] 3 [/SUP], Mi Seon Han[SUP] 2 4 [/SUP], Yoonsun Yoon[SUP] 5 [/SUP], Yun-Kyung Kim[SUP] 6 [/SUP], Hye-Kyung Cho[SUP] 7 [/SUP], Ki Wook Yun[SUP] 2 8 [/SUP], Seung Ha Song[SUP] 2 8 [/SUP], Bin Ahn[SUP] 2 8 [/SUP], Ye Kyung Kim[SUP] 2 8 [/SUP], Sung Hwan Choi[SUP] 8 [/SUP], Young June Choe[SUP] 9 [/SUP], Heeji Lim[SUP] 10 [/SUP], Eun Bee Choi[SUP] 10 [/SUP], Kwangwook Kim[SUP] 10 [/SUP], Seokhwan Hyeon[SUP] 10 [/SUP], Hye Jung Lim[SUP] 10 [/SUP], Byung-Chul Kim[SUP] 10 [/SUP], Yoo-Kyoung Lee[SUP] 10 [/SUP], Eun Hwa Choi[SUP] 2 8 [/SUP], Eui-Cheol Shin[SUP] 3 11 [/SUP], Hyunju Lee[SUP] 1 2 [/SUP]
Affiliations
- PMID: 37670807
- PMCID: PMC10475828
- DOI: 10.4110/in.2023.23.e33
Vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been acknowledged as an effective mean of preventing infection and hospitalization. However, the emergence of highly transmissible SARS-CoV-2 variants of concern (VOCs) has led to substantial increase in infections among children and adolescents. Vaccine-induced immunity and longevity have not been well defined in this population. Therefore, we aimed to analyze humoral and cellular immune responses against ancestral and SARS-CoV-2 variants after two shots of the BNT162b2 vaccine in healthy adolescents. Although vaccination induced a robust increase of spike-specific binding Abs and neutralizing Abs against the ancestral and SARS-CoV-2 variants, the neutralizing activity against the Omicron variant was significantly low. On the contrary, vaccine-induced memory CD4[SUP]+[/SUP] T cells exhibited substantial responses against both ancestral and Omicron spike proteins. Notably, CD4[SUP]+[/SUP] T cell responses against both ancestral and Omicron strains were preserved at 3 months after two shots of the BNT162b2 vaccine without waning. Polyfunctionality of vaccine-induced memory T cells was also preserved in response to Omicron spike protein. The present findings characterize the protective immunity of vaccination for adolescents in the era of continuous emergence of variants/subvariants.
Keywords: Adolescent; COVID-19 vaccines; SARS-CoV-2; SARS-CoV-2 variants.