tetano
Editor, Senior Moderator
Immune Netw
. 2023 Mar 31;23(2):e19.
doi: 10.4110/in.2023.23.e19. eCollection 2023 Apr. Pre-existing Immunity to Endemic Human Coronaviruses Does Not Affect the Immune Response to SARS-CoV-2 Spike in a Murine Vaccination Model
Ahn Young Jeong[SUP] 1 2 [/SUP], Pureum Lee[SUP] 1 2 [/SUP], Moo-Seung Lee[SUP] 2 3 [/SUP], Doo-Jin Kim[SUP] 1 2 4 [/SUP]
Affiliations
Endemic human coronaviruses (HCoVs) have been evidenced to be cross-reactive to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Although a correlation exists between the immunological memory to HCoVs and coronavirus disease 2019 (COVID-19) severity, there is little experimental evidence for the effects of HCoV memory on the efficacy of COVID-19 vaccines. Here, we investigated the Ag-specific immune response to COVID-19 vaccines in the presence or absence of immunological memory against HCoV spike Ags in a mouse model. Pre-existing immunity against HCoV did not affect the COVID-19 vaccine-mediated humoral response with regard to Ag-specific total IgG and neutralizing Ab levels. The specific T cell response to the COVID-19 vaccine Ag was also unaltered, regardless of pre-exposure to HCoV spike Ags. Taken together, our data suggest that COVID-19 vaccines elicit comparable immunity regardless of immunological memory to spike of endemic HCoVs in a mouse model.
Keywords: COVID-19 vaccine; Cross-reactivity; Human coronavirus (HCoV); Pre-existing immunity; SARS-CoV-2.
. 2023 Mar 31;23(2):e19.
doi: 10.4110/in.2023.23.e19. eCollection 2023 Apr. Pre-existing Immunity to Endemic Human Coronaviruses Does Not Affect the Immune Response to SARS-CoV-2 Spike in a Murine Vaccination Model
Ahn Young Jeong[SUP] 1 2 [/SUP], Pureum Lee[SUP] 1 2 [/SUP], Moo-Seung Lee[SUP] 2 3 [/SUP], Doo-Jin Kim[SUP] 1 2 4 [/SUP]
Affiliations
- PMID: 37179748
- PMCID: PMC10166660
- DOI: 10.4110/in.2023.23.e19
Endemic human coronaviruses (HCoVs) have been evidenced to be cross-reactive to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Although a correlation exists between the immunological memory to HCoVs and coronavirus disease 2019 (COVID-19) severity, there is little experimental evidence for the effects of HCoV memory on the efficacy of COVID-19 vaccines. Here, we investigated the Ag-specific immune response to COVID-19 vaccines in the presence or absence of immunological memory against HCoV spike Ags in a mouse model. Pre-existing immunity against HCoV did not affect the COVID-19 vaccine-mediated humoral response with regard to Ag-specific total IgG and neutralizing Ab levels. The specific T cell response to the COVID-19 vaccine Ag was also unaltered, regardless of pre-exposure to HCoV spike Ags. Taken together, our data suggest that COVID-19 vaccines elicit comparable immunity regardless of immunological memory to spike of endemic HCoVs in a mouse model.
Keywords: COVID-19 vaccine; Cross-reactivity; Human coronavirus (HCoV); Pre-existing immunity; SARS-CoV-2.