tetano
Editor, Senior Moderator
Immune Netw
. 2024 Apr 29;24(2):e18.
doi: 10.4110/in.2024.24.e18. eCollection 2024 Apr. Cytokine Storm Related to CD4[SUP]+[/SUP] T Cells in Influenza Virus-Associated Acute Necrotizing Encephalopathy
Shushu Wang[SUP] 1 [/SUP], Dongyao Wang[SUP] 2 3 [/SUP], Xuesong Wang[SUP] 1 [/SUP], Mingwu Chen[SUP] 1 [/SUP], Yanshi Wang[SUP] 4 [/SUP], Haoquan Zhou[SUP] 1 [/SUP], Yonggang Zhou[SUP] 5 6 [/SUP], Yong Lv[SUP] 1 [/SUP], Haiming Wei[SUP] 5 6 [/SUP]
Affiliations
Acute necrotizing encephalopathy (ANE) is a rare but deadly complication with an unclear pathogenesis. We aimed to elucidate the immune characteristics of H1N1 influenza virus-associated ANE (IANE) and provide a potential therapeutic approach for IANE. Seven pediatric cases from a concentrated outbreak of H1N1 influenza were included in this study. The patients' CD4[SUP]+[/SUP] T cells from peripheral blood decreased sharply in number but highly expressed Eomesodermin (Eomes), CD69 and PD-1, companied with extremely high levels of IL-6, IL-8 in the cerebrospinal fluid and plasma. Patient 2, who showed high fever and seizures and was admitted to the hospital very early in the disease course, received intravenous tocilizumab and subsequently showed a reduction in temperature and a stable conscious state 24 h later. In conclusion, a proinflammatory cytokine storm associated with activated CD4[SUP]+[/SUP] T cells may cause severe brain pathology in IANE. Tocilizumab may be helpful in treating IANE.
Keywords: Cytokine storm; Encephalopathy; Influenza.
. 2024 Apr 29;24(2):e18.
doi: 10.4110/in.2024.24.e18. eCollection 2024 Apr. Cytokine Storm Related to CD4[SUP]+[/SUP] T Cells in Influenza Virus-Associated Acute Necrotizing Encephalopathy
Shushu Wang[SUP] 1 [/SUP], Dongyao Wang[SUP] 2 3 [/SUP], Xuesong Wang[SUP] 1 [/SUP], Mingwu Chen[SUP] 1 [/SUP], Yanshi Wang[SUP] 4 [/SUP], Haoquan Zhou[SUP] 1 [/SUP], Yonggang Zhou[SUP] 5 6 [/SUP], Yong Lv[SUP] 1 [/SUP], Haiming Wei[SUP] 5 6 [/SUP]
Affiliations
- PMID: 38725671
- PMCID: PMC11076295
- DOI: 10.4110/in.2024.24.e18
Acute necrotizing encephalopathy (ANE) is a rare but deadly complication with an unclear pathogenesis. We aimed to elucidate the immune characteristics of H1N1 influenza virus-associated ANE (IANE) and provide a potential therapeutic approach for IANE. Seven pediatric cases from a concentrated outbreak of H1N1 influenza were included in this study. The patients' CD4[SUP]+[/SUP] T cells from peripheral blood decreased sharply in number but highly expressed Eomesodermin (Eomes), CD69 and PD-1, companied with extremely high levels of IL-6, IL-8 in the cerebrospinal fluid and plasma. Patient 2, who showed high fever and seizures and was admitted to the hospital very early in the disease course, received intravenous tocilizumab and subsequently showed a reduction in temperature and a stable conscious state 24 h later. In conclusion, a proinflammatory cytokine storm associated with activated CD4[SUP]+[/SUP] T cells may cause severe brain pathology in IANE. Tocilizumab may be helpful in treating IANE.
Keywords: Cytokine storm; Encephalopathy; Influenza.