tetano
Editor, Senior Moderator
Immun Inflamm Dis
. 2024 Jul;12(7):e1269.
doi: 10.1002/iid3.1269. Risk of intensive care unit admission and mortality in patients hospitalized due to influenza A or B and SARS‑CoV‑2 variants Omicron or Delta
Omid Rezahosseini[SUP] 1 [/SUP], Casper Roed[SUP] 1 2 3 [/SUP], Adin Sejdic[SUP] 1 2 [/SUP], Mads Frederik Eiberg[SUP] 1 [/SUP], Lene Nielsen[SUP] 4 [/SUP], Jonas Boel[SUP] 4 [/SUP], Caroline Klint Johannesen[SUP] 5 [/SUP], Maarten van Wijhe[SUP] 3 [/SUP], Kristina Træholt Franck[SUP] 6 [/SUP], Sisse Rye Ostrowski[SUP] 2 7 [/SUP], Birgitte Lindegaard[SUP] 1 2 [/SUP], Thea K Fischer[SUP] 3 5 6 8 [/SUP], Troels Bygum Knudsen[SUP] 1 [/SUP], Jon Gitz Holler[SUP] 1 [/SUP], Zitta Barrella Harboe[SUP] 1 2 6 [/SUP]; COVID‐19 Omicron Delta study group collaborators
Collaborators, Affiliations
Background: Respiratory viral infections have significant global health impacts. We compared 30-day intensive care unit (ICU) admission and all-cause mortality risks in patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Delta and Omicron variants versus influenza A and B (A/B).
Methods: Data from two retrospective inpatient cohorts in Capital Region of Denmark were analyzed. Cohorts included hospitalized influenza A/B patients (2017-2018) and SARS-CoV-2 Delta/Omicron patients (2021-2022), aged ≥18 years, admitted within 14 days of a positive real-time polymerase chain reaction test result. Cumulative ICU admission and mortality rates were estimated using the Aalen-Johansen estimator. Cox regression models calculated hazard ratios (HRs) for ICU admission and mortality.
Results: The study encompassed 1459 inpatients (Delta: 49%; Omicron: 26%; influenza A: 6.4%; and influenza B: 18%). Cumulative incidence of ICU admission was 11%, 4.0%, 7.5%, and 4.1%, for Delta, Omicron, influenza A, and B, respectively. For ICU admission, adjusted HRs (aHRs) were 3.1 (p < .001) and 1.5 (p = .34) for Delta and Omicron versus influenza B, and 1.5 (p = .36) and 0.71 (p = .48) versus influenza A. For mortality, aHRs were 3.8 (p < .001) and 3.4 (p < .001) for Delta and Omicron versus influenza B, and 2.1 (p = .04) and 1.9 (p = .11) versus influenza A.
Conclusion: Delta but not Omicron inpatients had an increased risk for ICU admission compared to influenza B; however, both variants were associated with higher risks of mortality than influenza B. Only Delta inpatients had a higher risk of mortality than influenza A inpatients.
Keywords: SARS‐CoV‐2 Delta variants; SARS‐CoV‐2 Omicron variant; influenza A; influenza B; intensive care units; mortality.
. 2024 Jul;12(7):e1269.
doi: 10.1002/iid3.1269. Risk of intensive care unit admission and mortality in patients hospitalized due to influenza A or B and SARS‑CoV‑2 variants Omicron or Delta
Omid Rezahosseini[SUP] 1 [/SUP], Casper Roed[SUP] 1 2 3 [/SUP], Adin Sejdic[SUP] 1 2 [/SUP], Mads Frederik Eiberg[SUP] 1 [/SUP], Lene Nielsen[SUP] 4 [/SUP], Jonas Boel[SUP] 4 [/SUP], Caroline Klint Johannesen[SUP] 5 [/SUP], Maarten van Wijhe[SUP] 3 [/SUP], Kristina Træholt Franck[SUP] 6 [/SUP], Sisse Rye Ostrowski[SUP] 2 7 [/SUP], Birgitte Lindegaard[SUP] 1 2 [/SUP], Thea K Fischer[SUP] 3 5 6 8 [/SUP], Troels Bygum Knudsen[SUP] 1 [/SUP], Jon Gitz Holler[SUP] 1 [/SUP], Zitta Barrella Harboe[SUP] 1 2 6 [/SUP]; COVID‐19 Omicron Delta study group collaborators
Collaborators, Affiliations
- PMID: 40499155
- PMCID: PMC11225085
- DOI: 10.1002/iid3.1269
Background: Respiratory viral infections have significant global health impacts. We compared 30-day intensive care unit (ICU) admission and all-cause mortality risks in patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Delta and Omicron variants versus influenza A and B (A/B).
Methods: Data from two retrospective inpatient cohorts in Capital Region of Denmark were analyzed. Cohorts included hospitalized influenza A/B patients (2017-2018) and SARS-CoV-2 Delta/Omicron patients (2021-2022), aged ≥18 years, admitted within 14 days of a positive real-time polymerase chain reaction test result. Cumulative ICU admission and mortality rates were estimated using the Aalen-Johansen estimator. Cox regression models calculated hazard ratios (HRs) for ICU admission and mortality.
Results: The study encompassed 1459 inpatients (Delta: 49%; Omicron: 26%; influenza A: 6.4%; and influenza B: 18%). Cumulative incidence of ICU admission was 11%, 4.0%, 7.5%, and 4.1%, for Delta, Omicron, influenza A, and B, respectively. For ICU admission, adjusted HRs (aHRs) were 3.1 (p < .001) and 1.5 (p = .34) for Delta and Omicron versus influenza B, and 1.5 (p = .36) and 0.71 (p = .48) versus influenza A. For mortality, aHRs were 3.8 (p < .001) and 3.4 (p < .001) for Delta and Omicron versus influenza B, and 2.1 (p = .04) and 1.9 (p = .11) versus influenza A.
Conclusion: Delta but not Omicron inpatients had an increased risk for ICU admission compared to influenza B; however, both variants were associated with higher risks of mortality than influenza B. Only Delta inpatients had a higher risk of mortality than influenza A inpatients.
Keywords: SARS‐CoV‐2 Delta variants; SARS‐CoV‐2 Omicron variant; influenza A; influenza B; intensive care units; mortality.