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Immun Inflamm Dis . Post-COVID pulmonary injury in K18-hACE2 mice shows persistent neutrophils and neutrophil extracellular trap formation

tetano

tetano

Editor, Senior Moderator
Immun Inflamm Dis


. 2024 Aug;12(8):e1343.
doi: 10.1002/iid3.1343. Post-COVID pulmonary injury in K18-hACE2 mice shows persistent neutrophils and neutrophil extracellular trap formation

Stefanos Giannakopoulos[SUP] 1 [/SUP], Juwon Park[SUP] 2 [/SUP], Jin Pak[SUP] 2 [/SUP], Michelle D Tallquist[SUP] 3 [/SUP], Saguna Verma[SUP] 2 [/SUP]



Affiliations
Abstract

The involvement of neutrophils in the lungs during the recovery phase of coronavirus disease 2019 (COVID-19) is not well defined mainly due to the limited accessibility of lung tissues from COVID-19 survivors. The lack of an appropriate small animal model has affected the development of effective therapeutic strategies. We here developed a long COVID mouse model to study changes in neutrophil phenotype and association with lung injury. Our data shows persistent neutrophil recruitment and neutrophil extracellular trap formation in the lungs for up to 30 days post-infection which correlates with lung fibrosis and inflammation.

Keywords: K18‐hACE2 mouse model; NETs; SARS‐CoV‐2; long COVID; neutrophils; pulmonary fibrosis.

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