tetano
Editor, Senior Moderator
Immun Inflamm Dis
. 2021 Nov 22.
doi: 10.1002/iid3.535. Online ahead of print.
Laboratory management for large-scale population screening for SARS-CoV-2
Xiuzhi Duan[SUP] 1 [/SUP], Dingfeng Lv[SUP] 2 [/SUP], Lin Wang[SUP] 1 [/SUP], Yanchao Liu[SUP] 3 [/SUP], Shu Zhang[SUP] 4 [/SUP], Weiwei Liu[SUP] 1 [/SUP], Jiamin Xie[SUP] 5 [/SUP], Chunqiang Gu[SUP] 6 [/SUP], Xiaosi Li[SUP] 7 [/SUP], Zhihua Tao[SUP] 1 [/SUP], Xiang Chen[SUP] 8 [/SUP], Qiang Yao[SUP] 9 [/SUP]
Affiliations
Abstract
Introduction: The aim of this study was to investigate the improvements in laboratory testing procedures and the quality and safety management for large-scale population screening for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Methods: Because of epidemic prevention and control needs in Hebei Province, on January 7, 2021, the Health Commission of Zhejiang Province sent a medical team to Hebei Province, to carry out SARS-CoV-2 nucleic acid testing. Screening for the SARS-CoV-2 nucleic acid test was performed using reverse-transcription polymerase chain reaction (RT-PCR). Practical tests and repeated process optimization were adopted to explore the optimal solution for improving laboratory testing procedures and the quality of and safety management for large-scale population screening for SARS-CoV-2.
Results: The Zhejiang medical team completed 250,000 pooled SARS-CoV-2 nucleic acid samples in 24 days in Shijiazhuang, with a peak daily testing capacity of 40,246 samples testing. There were no false-negative or false-positive results, and no laboratory personnel was infected with SARS-CoV-2. Significant achievements have been made in SARS-CoV-2 prevention and control.
Conclusions: This report summarizes the effort of the medical team regarding their management of the quality and safety of laboratory tests and proposes corresponding empirical recommendations to provide a reference for future large-scale population screening SARS-CoV-2.
Keywords: SARS-CoV-2; laboratory management; mass screening; nucleic acid detection.
. 2021 Nov 22.
doi: 10.1002/iid3.535. Online ahead of print.
Laboratory management for large-scale population screening for SARS-CoV-2
Xiuzhi Duan[SUP] 1 [/SUP], Dingfeng Lv[SUP] 2 [/SUP], Lin Wang[SUP] 1 [/SUP], Yanchao Liu[SUP] 3 [/SUP], Shu Zhang[SUP] 4 [/SUP], Weiwei Liu[SUP] 1 [/SUP], Jiamin Xie[SUP] 5 [/SUP], Chunqiang Gu[SUP] 6 [/SUP], Xiaosi Li[SUP] 7 [/SUP], Zhihua Tao[SUP] 1 [/SUP], Xiang Chen[SUP] 8 [/SUP], Qiang Yao[SUP] 9 [/SUP]
Affiliations
- PMID: 34808034
- DOI: 10.1002/iid3.535
Abstract
Introduction: The aim of this study was to investigate the improvements in laboratory testing procedures and the quality and safety management for large-scale population screening for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Methods: Because of epidemic prevention and control needs in Hebei Province, on January 7, 2021, the Health Commission of Zhejiang Province sent a medical team to Hebei Province, to carry out SARS-CoV-2 nucleic acid testing. Screening for the SARS-CoV-2 nucleic acid test was performed using reverse-transcription polymerase chain reaction (RT-PCR). Practical tests and repeated process optimization were adopted to explore the optimal solution for improving laboratory testing procedures and the quality of and safety management for large-scale population screening for SARS-CoV-2.
Results: The Zhejiang medical team completed 250,000 pooled SARS-CoV-2 nucleic acid samples in 24 days in Shijiazhuang, with a peak daily testing capacity of 40,246 samples testing. There were no false-negative or false-positive results, and no laboratory personnel was infected with SARS-CoV-2. Significant achievements have been made in SARS-CoV-2 prevention and control.
Conclusions: This report summarizes the effort of the medical team regarding their management of the quality and safety of laboratory tests and proposes corresponding empirical recommendations to provide a reference for future large-scale population screening SARS-CoV-2.
Keywords: SARS-CoV-2; laboratory management; mass screening; nucleic acid detection.