tetano
Editor, Senior Moderator
Immun Inflamm Dis
. 2021 Sep 16.
doi: 10.1002/iid3.532. Online ahead of print.
A single dose of the Biontech/Pfizer BNT162b2 vaccine protected elderly residents from severe COVID-19 during a SARS-coronavirus-2 outbreak in a senior citizen home in Germany
Rolf Schwarzer[SUP] 1 [/SUP], Sabine D Freys[SUP] 2 [/SUP], Nick Neuwinger[SUP] 1 [/SUP], Nina Beikert[SUP] 1 [/SUP], Bettina Eberspächer[SUP] 1 [/SUP], Anke Edelmann[SUP] 1 [/SUP], Marta Zuchowski[SUP] 1 [/SUP], Inga Slothouwer[SUP] 1 [/SUP], Angela Stein[SUP] 1 [/SUP], Kathrin Theil[SUP] 1 [/SUP], Peter Menzel[SUP] 1 [/SUP], Jörg Hofmann[SUP] 1 [/SUP]
Affiliations
Abstract
Background: A total of 62/66 (93.9%) residents in a senior citizen home in Bremen, Germany, received the first dose of the Biontech/Pfizer vaccine BNT162b2 on December 27th 2020. After routine severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antigen tests showed positive results on January 5th, all residents and staff were tested by RT-PCR.
Results: Nine staff members and 23 residents had a positive result. PCR positive staff members reported mild to severe COVID-19 symptoms, one was hospitalized. None of them had been vaccinated. In contrast, the vaccinated residents reported no or only mild symptoms. Sequencing of the SARS-CoV-2 genomes of infected individuals revealed a monophyletic origin of the outbreak within the PANGO lineage B.1.177.86.
Conclusions: In summary, our data show that partial vaccination prevented severe COVID-19 among the residents during this local SARS-CoV-2 outbreak, suggesting a high effectiveness of even a single vaccine dose, but also emphasize that asymptomatic individuals might still be carriers/spreaders.
Keywords: infections; processes; vaccination; viral/retroviral.
. 2021 Sep 16.
doi: 10.1002/iid3.532. Online ahead of print.
A single dose of the Biontech/Pfizer BNT162b2 vaccine protected elderly residents from severe COVID-19 during a SARS-coronavirus-2 outbreak in a senior citizen home in Germany
Rolf Schwarzer[SUP] 1 [/SUP], Sabine D Freys[SUP] 2 [/SUP], Nick Neuwinger[SUP] 1 [/SUP], Nina Beikert[SUP] 1 [/SUP], Bettina Eberspächer[SUP] 1 [/SUP], Anke Edelmann[SUP] 1 [/SUP], Marta Zuchowski[SUP] 1 [/SUP], Inga Slothouwer[SUP] 1 [/SUP], Angela Stein[SUP] 1 [/SUP], Kathrin Theil[SUP] 1 [/SUP], Peter Menzel[SUP] 1 [/SUP], Jörg Hofmann[SUP] 1 [/SUP]
Affiliations
- PMID: 34528766
- DOI: 10.1002/iid3.532
Abstract
Background: A total of 62/66 (93.9%) residents in a senior citizen home in Bremen, Germany, received the first dose of the Biontech/Pfizer vaccine BNT162b2 on December 27th 2020. After routine severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antigen tests showed positive results on January 5th, all residents and staff were tested by RT-PCR.
Results: Nine staff members and 23 residents had a positive result. PCR positive staff members reported mild to severe COVID-19 symptoms, one was hospitalized. None of them had been vaccinated. In contrast, the vaccinated residents reported no or only mild symptoms. Sequencing of the SARS-CoV-2 genomes of infected individuals revealed a monophyletic origin of the outbreak within the PANGO lineage B.1.177.86.
Conclusions: In summary, our data show that partial vaccination prevented severe COVID-19 among the residents during this local SARS-CoV-2 outbreak, suggesting a high effectiveness of even a single vaccine dose, but also emphasize that asymptomatic individuals might still be carriers/spreaders.
Keywords: infections; processes; vaccination; viral/retroviral.