tetano
Editor, Senior Moderator
Immun Inflamm Dis
. 2020 Aug 8.
doi: 10.1002/iid3.337. Online ahead of print.
A family cluster of diagnosed coronavirus disease 2019 (COVID-19) kidney transplant recipient in Thailand
Parichart Sakulkonkij[SUP] 1 [/SUP], Jackrapong Bruminhent[SUP] 2 [/SUP], Charan Pankongngam[SUP] 1 [/SUP], Nipon Chalermphunchai[SUP] 1 [/SUP]
Affiliations
Abstract
Introduction: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes an ongoing outbreak of respiratory illness called coronavirus disease 2019 (COVID-19). The clinical course could be ranging from mild to severe illness especially the individuals with an immunocompromised condition such as solid organ transplant recipients.
Method: We described a family cluster of COVID-19 patients who were admitted during 3rd April 2020 to 30th April 2020. COVID-19 was confirmed by a presence of SARS-CoV-2 ribonucleic acid in the respiratory specimens detected by a qualitative, real-time reverse transcription-polymerase chain reaction. The study focused on the clinical course and management of our cases.
Results: A family cluster of four laboratory-confirmed COVID-19 patients, one of those carried an underlying kidney transplant (KT) receiving immunosuppressants. Clinical presentation and severity of our case series are variable depending on each individual immune status. By far, a KT recipient seems to develop more severity despite antiviral therapy, cessation of immunosuppressant, and aggressive intensive care support.
Conclusion: Our case series plausibly affirmed a person-to-person transmission and potentially severe disease in the transplant population. Clinicians who are encountering with transplant recipients should be aware of possible transmission among family members.
Keywords: COVID-19; family cluster; pneumonia; post kidney transplant; transmission.
. 2020 Aug 8.
doi: 10.1002/iid3.337. Online ahead of print.
A family cluster of diagnosed coronavirus disease 2019 (COVID-19) kidney transplant recipient in Thailand
Parichart Sakulkonkij[SUP] 1 [/SUP], Jackrapong Bruminhent[SUP] 2 [/SUP], Charan Pankongngam[SUP] 1 [/SUP], Nipon Chalermphunchai[SUP] 1 [/SUP]
Affiliations
- PMID: 32770646
- DOI: 10.1002/iid3.337
Abstract
Introduction: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes an ongoing outbreak of respiratory illness called coronavirus disease 2019 (COVID-19). The clinical course could be ranging from mild to severe illness especially the individuals with an immunocompromised condition such as solid organ transplant recipients.
Method: We described a family cluster of COVID-19 patients who were admitted during 3rd April 2020 to 30th April 2020. COVID-19 was confirmed by a presence of SARS-CoV-2 ribonucleic acid in the respiratory specimens detected by a qualitative, real-time reverse transcription-polymerase chain reaction. The study focused on the clinical course and management of our cases.
Results: A family cluster of four laboratory-confirmed COVID-19 patients, one of those carried an underlying kidney transplant (KT) receiving immunosuppressants. Clinical presentation and severity of our case series are variable depending on each individual immune status. By far, a KT recipient seems to develop more severity despite antiviral therapy, cessation of immunosuppressant, and aggressive intensive care support.
Conclusion: Our case series plausibly affirmed a person-to-person transmission and potentially severe disease in the transplant population. Clinicians who are encountering with transplant recipients should be aware of possible transmission among family members.
Keywords: COVID-19; family cluster; pneumonia; post kidney transplant; transmission.